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Literature summary for 4.1.1.49 extracted from

  • Ahn, S.W.; Gang, G.T.; Tadi, S.; Nedumaran, B.; Kim, Y.D.; Park, J.H.; Kweon, G.R.; Koo, S.H.; Lee, K.; Ahn, R.S.; Yim, Y.H.; Lee, C.H.; Harris, R.A.; Choi, H.S.
    Phosphoenolpyruvate carboxykinase and glucose-6-phosphatase are required for steroidogenesis in testicular Leydig cells (2012), J. Biol. Chem., 287, 41875-41887.
    View publication on PubMedView publication on EuropePMC
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
ADP + phosphoenolpyruvate + CO2 Mus musculus
-
 ATP + oxaloacetate
-
 ?

Organism

Organism UniProt Comment Textmining
Mus musculus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
Leydig cell
-
 Mus musculus
-
testis
-
 Mus musculus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
ADP + phosphoenolpyruvate + CO2
-
 Mus musculus ATP + oxaloacetate
-
 ?

Synonyms

Synonyms Comment Organism
ADP-linked PEP carboxykinase
-
 Mus musculus
PEPCK
-
 Mus musculus

Cofactor

Cofactor Comment Organism Structure
ADP
-
 Mus musculus

Expression

Organism Comment Expression
Mus musculus pubertal mouse (8-week-old) testes and human chorionic gonadotropin-induced prepubertal mouse testes show increased enzyme expression up

General Information

General Information Comment Organism
malfunction lack of phosphoenolpyruvate carboxykinase leads to activation of AMP-activated protein kinase, which inhibits cAMP-induced steroidogenic gene promoter activity and gene expression Mus musculus
physiological function the enzyme is required for steroidogenesis in testicular Leydig cells Mus musculus