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Literature summary for 4.1.1.50 extracted from

  • Persson, K.; Aslund, L.; Grahn, B.; Hanke, J.; Heby, O.
    Trypanosoma cruzi has not lost its S-adenosylmethionine decarboxylase: characterization of the gene and the encoded enzyme (1998), Biochem. J., 333, 527-537.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.1.1.50

Activating Compound

Activating Compound Comment Organism Structure
putrescine stimulation Trypanosoma cruzi

Cloned(Commentary)

Cloned (Comment) Organism
expression in Escherichia coli Trypanosoma cruzi

Inhibitors

Inhibitors Comment Organism Structure
methylglyoxal bis(guanylhydrazone) poor Trypanosoma cruzi
spermidine weak Trypanosoma cruzi
spermine strong Trypanosoma cruzi

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.21
-
 S-adenosyl-L-methionine
-
 Trypanosoma cruzi

Organism

Organism UniProt Comment Textmining
Trypanosoma cruzi
-
-
-

Posttranslational Modification

Posttranslational Modification Comment Organism
proteolytic modification the recombinant protein undergoes autocatalytic cleavage, generating a 33000-34000 Da alpha-subunit and a 9000 Da beta-subunit Trypanosoma cruzi

Purification (Commentary)

Purification (Comment) Organism
recombinant enzyme Trypanosoma cruzi

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
 Trypanosoma cruzi (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?