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Literature summary for 4.1.1.50 extracted from
- S-Adenosylmethionine decarboxylase from the thermophilic archaebacterium Sulfolobus solfataricus (1991), Eur. J. Biochem., 199, 395-400.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| putrescine | no requirement | Saccharolobus solfataricus |  |
| pyruvate | covalently linked prosthetic group | Saccharolobus solfataricus | |
| pyruvate | contains approximately 0.8 mol pyruvate per mol of enzyme | Saccharolobus solfataricus | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| methylglyoxal bis(guanylhydrazone) | competitive | Saccharolobus solfataricus | |
| NaCNBH3 | in presence of substrate or product | Saccharolobus solfataricus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.96 | - |
S-adenosylmethionine | - |
Saccharolobus solfataricus | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| additional information | no requirement for a divalent metal ion | Saccharolobus solfataricus |
Molecular Weight [Da]
| Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
|---|---|---|---|
| 32000 | - |
1 * 32000, SDS-PAGE | Saccharolobus solfataricus |
| 36000 | - |
gel filtration | Saccharolobus solfataricus |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | Saccharolobus solfataricus | major regulatory enzyme in polyamine biosynthesis | ? | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Saccharolobus solfataricus | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
- |
Saccharolobus solfataricus |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| 0.012 | - |
- |
Saccharolobus solfataricus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| S-adenosyl-L-methionine | - |
Saccharolobus solfataricus | (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2 | - |
? | |
| S-adenosyl-L-methionine | major regulatory enzyme in polyamine biosynthesis | Saccharolobus solfataricus | ? | - |
? | |
Subunits
| Subunits | Comment | Organism |
|---|---|---|
| monomer | 1 * 32000, SDS-PAGE | Saccharolobus solfataricus |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 75 | - |
- |
Saccharolobus solfataricus |
Temperature Range [°C]
| Temperature Minimum [°C] | Temperature Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | 90 | 50°C: about 45% of maximal activity, 90°C: about 60% of maximal activity | Saccharolobus solfataricus |
Temperature Stability [°C]
| Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 50 | - |
16 h, stable | Saccharolobus solfataricus |
| 70 | - |
16h, 20% loss of activity | Saccharolobus solfataricus |
| 100 | - |
1 h, 80% loss of activity | Saccharolobus solfataricus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.4 | - |
- |
Saccharolobus solfataricus |
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Release 2023.1 (January 2023)
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