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Literature summary for 4.1.1.50 extracted from

  • Blavid, R.; Kusch, P.; Hauber, J.; Eschweiler, U.; Sarite, S.R.; Specht, S.; Deininger, S.; Hoerauf, A.; Kaiser, A.
    Down-regulation of hypusine biosynthesis in plasmodium by inhibition of S-adenosyl-methionine-decarboxylase (2010), Amino Acids, 38, 461-469.
    View publication on PubMed
Search for more literature for 4.1.1.50

Inhibitors

Inhibitors Comment Organism Structure
CGP 48664A i.e. 4-amidinoindan-1-one-20-amidinohydrazone, also known as SAM486A Plasmodium falciparum

Organism

Organism UniProt Comment Textmining
Plasmodium falciparum
-
-
-
Plasmodium falciparum NF54
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
 Plasmodium falciparum (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?
S-adenosyl-L-methionine
-
 Plasmodium falciparum NF54 (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?

Synonyms

Synonyms Comment Organism
Ado-MetDC
-
 Plasmodium falciparum
S-adenosyl-methionine-decarboxylase
-
 Plasmodium falciparum

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate
-
 Plasmodium falciparum

General Information

General Information Comment Organism
metabolism key enzyme in the biosynthesis of spermidine Plasmodium falciparum