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Literature summary for 4.1.1.50 extracted from

  • Hirth, B.; Barker, R.H.; Celatka, C.A.; Klinger, J.D.; Liu, H.; Nare, B.; Nijjar, A.; Phillips, M.A.; Sybertz, E.; Willert, E.K.; Xiang, Y.
    Discovery of new S-adenosylmethionine decarboxylase inhibitors for the treatment of Human African Trypanosomiasis (HAT) (2009), Bioorg. Med. Chem. Lett., 19, 2916-2919.
    View publication on PubMed
Search for more literature for 4.1.1.50

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4R,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-ol
-
 Trypanosoma brucei
(2R,3R,4S,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-9H-purin-9-yl)-4-fluorotetrahydrofuran-3-ol
-
 Trypanosoma brucei
(2R,3S,4R,5R)-2-([[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]methyl)-5-(6-amino-2-chloro-9H-purin-9-yl)tetrahydrofuran-3,4-diol
-
 Trypanosoma brucei
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-2-methyladenosine
-
 Trypanosoma brucei
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-ethyladenosine
-
 Trypanosoma brucei
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-methyladenosine
-
 Trypanosoma brucei
5'-[[(2Z)-4-aminobut-2-en-1-yl](methyl)amino]-5'-deoxy-8-propyladenosine
-
 Trypanosoma brucei
MDL73811
-
 Trypanosoma brucei

Organism

Organism UniProt Comment Textmining
Trypanosoma brucei
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
S-adenosyl-L-methionine
-
 Trypanosoma brucei (5-deoxy-5-adenosyl)(3-aminopropyl)methylsulfonium salt + CO2
-
 ?

Synonyms

Synonyms Comment Organism
AdoMetDC
-
 Trypanosoma brucei
S-Adenosylmethionine decarboxylase
-
 Trypanosoma brucei