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Literature summary for 4.1.1.50 extracted from

  • Paasinen-Sohns, A.; Kaeaeriaeinen, E.; Yin, M.; Jaervinen, K.; Nummela, P.; Hoelttae, E.
    Chaotic neovascularization induced by aggressive fibrosarcoma cells overexpressing S-adenosylmethionine decarboxylase (2011), Int. J. Biochem. Cell Biol., 43, 441-454.
    View publication on PubMed
Search for more literature for 4.1.1.50

Cloned(Commentary)

Cloned (Comment) Organism
expressed in Amdc-s cells (NIH3T3 cells transfected with human AdoMetDC cDNA) Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
CGP 48664 specific inhibitor of AdoMetDC Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
 Homo sapiens
-
fibrosarcoma cell
-
 Homo sapiens
-
HT-1080 cell
-
 Homo sapiens
-
MDA-MB-231 cell
-
 Homo sapiens
-

Synonyms

Synonyms Comment Organism
AdoMetDC
-
 Homo sapiens
S-Adenosylmethionine decarboxylase
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction overexpression of S-adenosylmethionine decarboxylase in rodent fibroblasts leads to aggressive transformants (Amdc-s cells) that have high invasive capacity in nude mice, invading rapidly from the subcutaneous injection site into the peritoneal cavity and its organs. Amdc-s-induced tumors show chaotic neovascularization, with abundant pleomorphic vessel-like structures that have noncontiguous or totally missing laminin (basement membrane) and CD31 (endothelial cell) immunoreactivity Homo sapiens
physiological function S-adenosylmethionine decarboxylase is a key enzyme in the biosynthesis of polyamines essential for cell proliferation Homo sapiens