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Literature summary for 4.1.1.9 extracted from

  • Lee, G.Y.; Kim, N.H.; Zhao, Z.S.; Cha, B.S.; Kim, Y.S.
    Peroxisomal-proliferator-activated receptor alpha activates transcription of the rat hepatic malonyl-CoA decarboxylase gene: a key regulation of malonyl-CoA level (2004), Biochem. J., 378, 983-990.
    View publication on PubMedView publication on EuropePMC

Activating Compound

Activating Compound Comment Organism Structure
fenofibrate increases hepatic mRNA expression and MCD activity Rattus norvegicus
additional information peroxisomal-proliferator-activated receptor alpha activates transcription of hepatic MCD gene by binding of peroxisomal-proliferator-activated receptor alpha/retinoid X receptor alpha on two PPRE sites, WY14643-treated H4IIE hepatoma cells show increased MCD mRNA expression Rattus norvegicus

Cloned(Commentary)

Cloned (Comment) Organism
-
Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
Malonyl-CoA Rattus norvegicus important role in the regulation of malonyl-CoA concentration, role in the regulation of fatty-acid oxidation, may play a role in lipid catabolism by peroxisomal-proliferator-activated receptor alpha, which transcriptionally regulates the MCD gene Acetyl-CoA + CO2
-
?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
-
fenofibrate-fed Otsuka Long-Evans Tokushima fatty rats
-

Purification (Commentary)

Purification (Comment) Organism
partial, from liver Rattus norvegicus

Source Tissue

Source Tissue Comment Organism Textmining

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Rattus norvegicus

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
Malonyl-CoA
-
Rattus norvegicus Acetyl-CoA + CO2
-
?
Malonyl-CoA important role in the regulation of malonyl-CoA concentration, role in the regulation of fatty-acid oxidation, may play a role in lipid catabolism by peroxisomal-proliferator-activated receptor alpha, which transcriptionally regulates the MCD gene Rattus norvegicus Acetyl-CoA + CO2
-
?

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
30
-
assay at Rattus norvegicus

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8
-
assay at Rattus norvegicus