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Literature summary for 4.1.1.90 extracted from
- Vitamin K-dependent carboxylase: partial purification of the enzyme by antibody affinity techniques (1989), Thromb. Res., 56, 317-323.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-chloro-3-phytyl-1,4-naphthoquinone | - |
Bos taurus |  |
| tetrachloropyridin | - |
Bos taurus | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| microsome | from a dicoumarol-treated cow | Bos taurus | - |
- |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate + CO2 + O2 + vitamin K hydroquinone | Bos taurus | - |
gamma-carboxy L-glutamate + vitamin K epoxide + H2O | - |
? | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bos taurus | Q07175 | - |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial purification of the enzyme by antibody affinity techniques. Purified 500fold by adsorption to an antiprothrombin column and elution with a dodeca peptide which competes with a prothrombin precursor enzyme recognition site. The purified enzyme is devoid of bound precursors, and has the same ratio of vitamin K epoxidase activity to carboxylase activity as the crude microsomal preparation | Bos taurus |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| liver | - |
Bos taurus | - |
Specific Activity [micromol/min/mg]
| Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
|---|---|---|---|
| additional information | - |
propeptide eluate of gel: 608 U/mg, carboxylase units are expressed as 100000 dpm of 14CO2 fixed in the standard assay | Bos taurus |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| L-glutamate + CO2 + O2 + vitamin K hydroquinone | - |
Bos taurus | gamma-carboxy L-glutamate + vitamin K epoxide + H2O | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| glutamate carboxylase | - |
Bos taurus |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| vitamin K | - |
Bos taurus | |
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Release 2023.1 (January 2023)
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