Literature summary for 4.1.2.13 extracted from

Gavalda, S.; Braga, R.; Dax, C.; Vigroux, A.; Blonski, C.
N-Sulfonyl hydroxamate derivatives as inhibitors of class II fructose-1,6-diphosphate aldolase (2005), Bioorg. Med. Chem., 15, 5375-5377.

Search for more literature for 4.1.2.13

Inhibitors

Inhibitors	Comment	Organism	Structure
2-oxo-2-[(phenylsulfonyl)amino]ethyl phosphate	-	Escherichia coli
2-[(methylsulfonyl)amino]-2-oxoethyl phosphate	-	Escherichia coli
phosphoglycolo hydroxamic acid	PGH, i.e. 2-(hydroxyamino)-2-oxoethyl phosphate	Escherichia coli
phosphoglycolo hydroxamic acid	PGH, i.e. 2-(hydroxyamino)-2-oxoethyl phosphate	Oryctolagus cuniculus

KM Value [mM]

KM Value [mM]	KM Value Maximum [mM]	Substrate	Comment	Organism	Structure
0.01	-	D-fructose 1,6-bisphosphate	-	Oryctolagus cuniculus
0.3	-	D-fructose 1,6-bisphosphate	-	Escherichia coli

Organism

Organism	UniProt	Comment	Textmining
Escherichia coli	-	-	-
Oryctolagus cuniculus	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
D-fructose 1,6-bisphosphate	-	Escherichia coli	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?
D-fructose 1,6-bisphosphate	-	Oryctolagus cuniculus	glycerone phosphate + D-glyceraldehyde 3-phosphate	-	?

Ki Value [mM]

Ki Value [mM]	Ki Value maximum [mM]	Inhibitor	Comment	Organism	Structure
0.00001	-	phosphoglycolo hydroxamic acid	-	Escherichia coli
0.001	-	phosphoglycolo hydroxamic acid	-	Oryctolagus cuniculus
0.1	-	2-oxo-2-[(phenylsulfonyl)amino]ethyl phosphate	-	Escherichia coli
0.35	-	2-[(methylsulfonyl)amino]-2-oxoethyl phosphate	-	Escherichia coli

Use of this online version of BRENDA is free under the CC BY 4.0 license. See terms of use for full details.

Release 2023.1 (January 2023)