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Literature summary for 4.1.2.13 extracted from
- New highly selective inhibitors of class II fructose-1,6-bisphosphate aldolases (2004), Bioorg. Med. Chem. Lett., 14, 2923-2926.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 2-[(trihydroxyphosphoranyl)oxy]acetohydrazide | - |
Bacillus subtilis |  |
| 2-[(trihydroxyphosphoranyl)oxy]acetohydrazide | - |
Oryctolagus cuniculus | |
| N'-hydroxy-2-[(trihydroxyphosphoranyl)oxy]ethanimidamide | - |
Bacillus subtilis | |
| N-hydroxy-2-[(trihydroxyphosphoranyl)oxy]acetamide | - |
Oryctolagus cuniculus | |
| phosphoglycolo hydroxamic acid | PGH, i.e. 2-(hydroxyamino)-2-oxoethyl phosphate | Saccharomyces cerevisiae | |
| phosphoglycolo-amidoxime | PGA, i.e. 2-amino-2-(hydroxyimino)ethyl phosphate | Saccharomyces cerevisiae | |
| phosphoglycolo-hydrazide | PGHz, i.e. 2-hydrazino-2-oxoethyl phosphate | Saccharomyces cerevisiae | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.055 | - |
D-fructose 1,6-bisphosphate | - |
Saccharomyces cerevisiae | |
| 2 | - |
D-fructose 1,6-bisphosphate | - |
Bacillus subtilis | |
| 2 | - |
D-fructose 1,6-bisphosphate | - |
Oryctolagus cuniculus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Bacillus subtilis | - |
- |
- |
| Oryctolagus cuniculus | - |
- |
- |
| Saccharomyces cerevisiae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| D-fructose 1,6-bisphosphate | - |
Bacillus subtilis | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Saccharomyces cerevisiae | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
| D-fructose 1,6-bisphosphate | - |
Oryctolagus cuniculus | glycerone phosphate + D-glyceraldehyde 3-phosphate | - |
? | |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.00001 | - |
phosphoglycolo hydroxamic acid | - |
Saccharomyces cerevisiae | |
| 0.00034 | - |
phosphoglycolo-hydrazide | - |
Saccharomyces cerevisiae | |
| 0.00067 | - |
2-[(trihydroxyphosphoranyl)oxy]acetohydrazide | - |
Bacillus subtilis | |
| 0.001 | - |
N-hydroxy-2-[(trihydroxyphosphoranyl)oxy]acetamide | - |
Oryctolagus cuniculus | |
| 0.0023 | - |
phosphoglycolo-amidoxime | - |
Saccharomyces cerevisiae | |
| 0.0033 | - |
N'-hydroxy-2-[(trihydroxyphosphoranyl)oxy]ethanimidamide | - |
Bacillus subtilis | |
| 0.37 | - |
2-[(trihydroxyphosphoranyl)oxy]acetohydrazide | - |
Oryctolagus cuniculus | |
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