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Literature summary for 4.1.3.1 extracted from

  • Takao, S.; Takahashi, T.; Tanida, M.; Takahashi, M.
    Purification and some properties of isocitrate lyase from Paecilomyces varioti with high malic acid production (1984), J. Ferment. Technol., 62, 577-582.
No PubMed abstract available

Inhibitors

Inhibitors Comment Organism Structure
2-oxoglutarate
-
Paecilomyces variotii
citrate no inhibition at 0.1 mM Paecilomyces variotii
fumarate no inhibition at 0.1 mM Paecilomyces variotii
malate no inhibition at 0.1 mM Paecilomyces variotii
oxalacetate
-
Paecilomyces variotii
phosphoenolpyruvate
-
Paecilomyces variotii
pyruvate
-
Paecilomyces variotii
succinate
-
Paecilomyces variotii

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.018
-
threo-Ds-isocitrate
-
Paecilomyces variotii

Metals/Ions

Metals/Ions Comment Organism Structure
Mg2+ increase of activity Paecilomyces variotii
Mn2+ Mn2+ less effective activator than Mg2+ Paecilomyces variotii

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
240000
-
gel filtration Paecilomyces variotii

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate Paecilomyces variotii glyoxylate cycle ?
-
?

Organism

Organism UniProt Comment Textmining
Paecilomyces variotii
-
-
-

Oxidation Stability

Oxidation Stability Organism
dithiothreitol very effective in protecting enzyme from loss of activity Paecilomyces variotii

Purification (Commentary)

Purification (Comment) Organism
-
Paecilomyces variotii

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
103
-
-
Paecilomyces variotii

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2R,3S)-isocitrate
-
Paecilomyces variotii succinate + glyoxylate
-
?
isocitrate
-
Paecilomyces variotii succinate + glyoxylate
-
r
isocitrate glyoxylate cycle Paecilomyces variotii ?
-
?

Subunits

Subunits Comment Organism
tetramer 4*60000, SDS-PAGE Paecilomyces variotii

Temperature Optimum [°C]

Temperature Optimum [°C] Temperature Optimum Maximum [°C] Comment Organism
37
-
-
Paecilomyces variotii

Temperature Range [°C]

Temperature Minimum [°C] Temperature Maximum [°C] Comment Organism
20 50
-
Paecilomyces variotii

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
65
-
40% activity lost after 15 min Paecilomyces variotii

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.2
-
-
Paecilomyces variotii
7.5
-
-
Paecilomyces variotii

pH Range

pH Minimum pH Maximum Comment Organism
6.2 8
-
Paecilomyces variotii