Activating Compound | Comment | Organism | Structure |
---|---|---|---|
2-mercaptoethanol | 41% increase of activity at 1 mM | Fomitopsis palustris | |
dithiothreitol | 65% increase of activity at 1 mM | Fomitopsis palustris | |
glutathione | 35% increase of activity at 1 mM | Fomitopsis palustris | |
L-cysteine | 45% increase of activity at 1 mM | Fomitopsis palustris |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
4-chloromercuribenzoate | complete inactivation at 0.001 mM | Fomitopsis palustris | |
iodoacetate | isocitrate protects | Fomitopsis palustris | |
Itaconate | 89% inhibition at 1 mM | Fomitopsis palustris | |
oxalate | 86% inhibition at 10 mM | Fomitopsis palustris | |
oxaloacetate | 89% inhibition at 10 mM | Fomitopsis palustris | |
pyruvate | 87% inhibition at 10 mM | Fomitopsis palustris |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.092 | - |
Mg2+ | pH 7 | Fomitopsis palustris | |
1.6 | - |
DL-isocitrate | pH 7 | Fomitopsis palustris |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | requirement, optimal concentration: 2 mM, Km value: 0.092 at pH 7 | Fomitopsis palustris | |
Mn2+ | can replace Mg2+ with 24% of the activity of Mg2+ | Fomitopsis palustris |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
60000 | - |
3 * 60000, SDS-PAGE | Fomitopsis palustris |
186000 | - |
gel filtration | Fomitopsis palustris |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate | Fomitopsis palustris | regulatory enzyme playing a crucial role in fungal growth | succinate + glyoxylate | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Fomitopsis palustris | - |
- |
- |
Purification (Comment) | Organism |
---|---|
76fold | Fomitopsis palustris |
Specific Activity Minimum [µmol/min/mg] | Specific Activity Maximum [µmol/min/mg] | Comment | Organism |
---|---|---|---|
30.3 | - |
- |
Fomitopsis palustris |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
isocitrate | - |
Fomitopsis palustris | succinate + glyoxylate | - |
? | |
isocitrate | regulatory enzyme playing a crucial role in fungal growth | Fomitopsis palustris | succinate + glyoxylate | - |
? |
Subunits | Comment | Organism |
---|---|---|
trimer | 3 * 60000, SDS-PAGE | Fomitopsis palustris |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
32 | - |
DL-isocitrate | pH 7 | Fomitopsis palustris |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
7 | - |
- |
Fomitopsis palustris |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
5 | 8.5 | 50% activity at pH 5, 22% activity at pH 8.5, no activity at pH 9 | Fomitopsis palustris |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.037 | - |
oxalate | pH 7 | Fomitopsis palustris | |
0.068 | - |
Itaconate | pH 7 | Fomitopsis palustris |