Literature summary for 4.1.3.1 extracted from

Lee, H.S.; Yoon, K.M.; Han, Y.R.; Lee, K.J.; Chung, S.C.; Kim, T.I.; Lee, S.H.; Shin, J.; Oh, K.B.
5-Hydroxyindole-type alkaloids, as Candida albicans isocitrate lyase inhibitors, from the tropical sponge Hyrtios sp (2009), Bioorg. Med. Chem. Lett., 19, 1051-1053.

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Application

Application	Comment	Organism
drug development	isocitrate lyase inhibitor design, substitution of a functional group at position C3 in 5-hydroxyindole-type alkaloids by hydrophilic group increases inhibitory activity	Candida albicans

Cloned(Commentary)

Cloned (Comment)	Organism
from genomic DNA	Candida albicans

Inhibitors

Inhibitors	Comment	Organism	Structure
1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline	weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)	Candida albicans
5-hydroxy-1H-indole-3-carboxylic acid methyl ester	weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)	Candida albicans
5-hydroxyindole-3-carbaldehyde	moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)	Candida albicans
hyrtiosin A	moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)	Candida albicans
hyrtiosin B	strong inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)	Candida albicans
additional information	6-hydroxy-3,4-dihydro-1-oxo-beta-carboline, isolated from marine sponge Hyrtios sp. (Thorectidae family), defined inactive as inhibitor since IC50 is higher than 0.989 mM at a concentration of 2 mg/ml	Candida albicans
serotonin	moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family)	Candida albicans

Organism

Organism	UniProt	Comment	Textmining
Candida albicans	-	ATCC 10231	-

Synonyms

Synonyms	Comment	Organism
isocitrate lyase	-	Candida albicans

IC50 Value

IC50 Value	IC50 Value Maximum	Comment	Organism	Inhibitor	Structure
0.089	-	0.285 mg/ml	Candida albicans	hyrtiosin B
0.247	-	0.0398 mg/ml	Candida albicans	5-hydroxyindole-3-carbaldehyde
0.301	-	0.053 mg/ml	Candida albicans	serotonin
0.318	-	0.061 mg/ml	Candida albicans	hyrtiosin A
0.379	-	0.874 mg/ml	Candida albicans	1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline
0.799	-	0.153 mg/ml	Candida albicans	5-hydroxy-1H-indole-3-carboxylic acid methyl ester

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Release 2023.1 (January 2023)