Application | Comment | Organism |
---|---|---|
drug development | isocitrate lyase inhibitor design, substitution of a functional group at position C3 in 5-hydroxyindole-type alkaloids by hydrophilic group increases inhibitory activity | Candida albicans |
Cloned (Comment) | Organism |
---|---|
from genomic DNA | Candida albicans |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline | weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family) | Candida albicans | |
5-hydroxy-1H-indole-3-carboxylic acid methyl ester | weak inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family) | Candida albicans | |
5-hydroxyindole-3-carbaldehyde | moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family) | Candida albicans | |
hyrtiosin A | moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family) | Candida albicans | |
hyrtiosin B | strong inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family) | Candida albicans | |
additional information | 6-hydroxy-3,4-dihydro-1-oxo-beta-carboline, isolated from marine sponge Hyrtios sp. (Thorectidae family), defined inactive as inhibitor since IC50 is higher than 0.989 mM at a concentration of 2 mg/ml | Candida albicans | |
serotonin | moderate inhibition, isolated from marine sponge Hyrtios sp. (Thorectidae family) | Candida albicans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
ATCC 10231 | - |
Synonyms | Comment | Organism |
---|---|---|
isocitrate lyase | - |
Candida albicans |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.089 | - |
0.285 mg/ml | Candida albicans | hyrtiosin B | |
0.247 | - |
0.0398 mg/ml | Candida albicans | 5-hydroxyindole-3-carbaldehyde | |
0.301 | - |
0.053 mg/ml | Candida albicans | serotonin | |
0.318 | - |
0.061 mg/ml | Candida albicans | hyrtiosin A | |
0.379 | - |
0.874 mg/ml | Candida albicans | 1-carboxy-6-hydroxy-3,4-dihydro-beta-carboline | |
0.799 | - |
0.153 mg/ml | Candida albicans | 5-hydroxy-1H-indole-3-carboxylic acid methyl ester |