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Literature summary for 4.1.3.1 extracted from

  • Gengenbacher, M.; Rao, S.P.; Pethe, K.; Dick, T.
    Nutrient-starved, non-replicating Mycobacterium tuberculosis requires respiration, ATP synthase and isocitrate lyase for maintenance of ATP homeostasis and viability (2010), Microbiology, 156, 81-87.
    View publication on PubMed
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Cloned(Commentary)

Cloned (Comment) Organism
ICL loss-of-function mutant strain DELTAicl complemented with the functional ICL gene using the integrative vector pMV306 Mycobacterium tuberculosis

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WKK7
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Mycobacterium tuberculosis H37Rv P9WKK7
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-

Synonyms

Synonyms Comment Organism
ICL
-
 Mycobacterium tuberculosis
isocitrate lyase
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 Mycobacterium tuberculosis

General Information

General Information Comment Organism
malfunction nutrient-starved bacilli lacking the glyoxylate shunt enzyme isocitrate lyase fail to reduce their intracellular ATP level and die, thus establishing a link between ATP control and intermediary metabolism. ICL loss-of-function mutant dies in the Loebel model. Viability is fully restored when the mutant strain is complemented with a wild-type copy of ICL Mycobacterium tuberculosis
physiological function ICL gene is required for non-growing survival in the Loebel model (nutrient deprivation in oxygen-rich medium) Mycobacterium tuberculosis