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Literature summary for 4.1.3.1 extracted from

  • Lee, Y.V.; Wahab, H.A.; Choong, Y.S.
    Potential inhibitors for isocitrate lyase of Mycobacterium tuberculosis and non-M. tuberculosis a summary (2015), BioMed Res. Int., 2015, 895453 .
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
(2R,3R,4S,6E)-2-amino-1,3-dihydroxy-16-methylheptadec-6-en-4-yl hydrogen sulfate
-
Candida albicans
(2S,7E)-9-(2,5-dihydroxyphenyl)-7-methyl-1-[(1S,4aS,8aS)-2,5,5,8a-tetramethyl-1,4,4a,5,6,7,8,8a-octahydronaphthalen-1-yl]non-7-en-2-yl sulfate
-
Pyricularia grisea
(5bR,7aS,11aR,11bS,13R,13aS,13bS)-1-hydroxy-11a-(hydroxymethyl)-5b,8,8,13a-tetramethyl-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-13-yl acetate
-
Candida albicans
(5bR,7aS,11aS,11bR,13R,13aS,13bR)-1-methoxy-5b,8,8,11a,13a-pentamethyl-3-oxo-1,3,5,5a,5b,6,7,7a,8,9,10,11,11a,11b,12,13,13a,13b-octadecahydrochryseno[1,2-c]furan-13-yl acetate
-
Candida albicans
(5Z)-4-(3,5-dibromo-4-hydroxyphenyl)-3-[(S)-(3,5-dibromo-4-methoxyphenyl)(hydroxy)methyl]-5-(3-methoxybenzylidene)furan-2(5H)-one
-
Candida albicans
(5Z)-4-(3-bromo-4-hydroxyphenyl)-3-(3,5-dibromo-4-hydroxybenzoyl)-5-[(2,4-dibromo-3-hydroxyphenyl)methylidene]furan-2(5H)-one
-
Candida albicans
1-(3-methoxyphenyl)-2,3,4,4a,9,9a-hexahydro-1H-b-carboline
-
Candida albicans
1-(5-hydroxy-1H-indol-3-yl)-2-(6-hydroxy-1H-indol-3-yl)ethane-1,2-dione i.e. hyrtiosin B Candida albicans
1-cyclopropyl-6-fluoro-7-[4-([(3Z)-3-[2-(methoxycarbamothioyl)hydrazinylidene]-5-methyl-2-oxo-2,3-dihydro-1H-indol-1-yl]methyl)piperazin-1-yl]-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
Mycobacterium tuberculosis
1-ethyl-4-hydroxy-2-oxo-N'-tridecanoyl-1,2,3,4-tetrahydroquinoline-3-carbohydrazide
-
Mycobacterium tuberculosis
2,5-dichloro-3-[(3E)-4-chloro-3-methylbut-3-en-1-yn-1-yl]-6-hydroxycyclohexa-2,5-diene-1,4-dione
-
Acinetobacter calcoaceticus
2,5-dichloro-3-[(3E)-4-chloro-3-methylbut-3-en-1-yn-1-yl]-6-hydroxycyclohexa-2,5-diene-1,4-dione
-
Neurospora crassa
2,5-dichloro-3-[(3E)-4-chloro-3-methylbut-3-en-1-yn-1-yl]-6-hydroxycyclohexa-2,5-diene-1,4-dione
-
Ricinus communis
2-(4-hydroxyphenyl)-1-(5H-pyrido[4,3-b]indol-3-yl)ethan-1-one
-
Candida albicans
2-methylidenebutanedioic acid i.e. itaconate Vogesella indigofera
3-Bromopyruvate
-
Escherichia coli
3-nitropropanoate
-
Vogesella indigofera
4,4'-(hexane-1,1-diyl)bis(6-bromobenzene-1,3-diol)
-
Candida albicans
4,4'-methylenebis(5,6-dibromobenzene-1,2-diol)
-
Pyricularia grisea
4-cyclopropyl-6-[3,5-dimethyl-4-(4-nitro-2-oxobutyl)piperazin-1-yl]-7-fluoro-5-methoxy-1-oxo-1,4,7,8-tetrahydronaphthalene-2-carboxylic acid
-
Mycobacterium tuberculosis
4-[2-hydroxy-2-(5H-pyrido[4,3-b]indol-3-yl)ethyl]phenol
-
Candida albicans
4-[[1-(4-chlorophenyl)-5-(6-methoxynaphthalen-2-yl)-3-oxopentyl]amino]benzoic acid
-
Mycobacterium tuberculosis
5-bromo-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl N-prop-1-en-2-yl-L-phenylalaninate
-
Mycobacterium tuberculosis
5-chloro-2-[[4-(trifluoromethyl)phenyl]carbamoyl]phenyl pyrazine-2-carboxylate
-
Mycobacterium tuberculosis
5-nitro-N'-[(E)-(5-nitrofuran-2-yl)methylidene]furan-2-carbohydrazide
-
Mycobacterium tuberculosis
7-[3,5-dimethyl-4-[(5-nitro-2,6-dioxohexahydropyrimidin-4-yl)carbonyl]piperazin-1-yl]-1-ethyl-6,8-difluoro-4-oxo-1,4-dihydroquinoline-3-carboxylic acid
-
Mycobacterium tuberculosis
Bahamaolide A
-
Candida albicans
bis(2,3-dibromo-4,5-dihydroxyphenyl)methanone
-
Candida albicans
DNAzyme
-
Mycobacterium tuberculosis
methyl 2-[bis(3,5-dibromo-4-hydroxyphenyl)methylidene]-4-(3,5-dibromo-4-hydroxyphenyl)-5-oxo-2,5-dihydrofuran-3-carboxylate
-
Candida albicans
sodium 2,3-dihydroxypropyl (2R)-3-[[10-(2-hexylcyclopropyl)decanoyl]oxy]-2-hydroxypropyl phosphate
-
Candida albicans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
isocitrate Escherichia coli
-
succinate + glyoxylate
-
?
isocitrate Neurospora crassa
-
succinate + glyoxylate
-
?
isocitrate Acinetobacter calcoaceticus
-
succinate + glyoxylate
-
?
isocitrate Mycobacterium tuberculosis
-
succinate + glyoxylate
-
?
isocitrate Ricinus communis
-
succinate + glyoxylate
-
?
isocitrate Pyricularia grisea
-
succinate + glyoxylate
-
?
isocitrate Vogesella indigofera
-
succinate + glyoxylate
-
?
isocitrate Candida albicans
-
succinate + glyoxylate
-
?

Organism

Organism UniProt Comment Textmining
Acinetobacter calcoaceticus
-
-
-
Candida albicans Q9P8Q7
-
-
Escherichia coli
-
-
-
Mycobacterium tuberculosis
-
-
-
Neurospora crassa
-
-
-
Pyricularia grisea
-
-
-
Ricinus communis
-
-
-
Vogesella indigofera
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
isocitrate
-
Escherichia coli succinate + glyoxylate
-
?
isocitrate
-
Neurospora crassa succinate + glyoxylate
-
?
isocitrate
-
Acinetobacter calcoaceticus succinate + glyoxylate
-
?
isocitrate
-
Mycobacterium tuberculosis succinate + glyoxylate
-
?
isocitrate
-
Ricinus communis succinate + glyoxylate
-
?
isocitrate
-
Pyricularia grisea succinate + glyoxylate
-
?
isocitrate
-
Vogesella indigofera succinate + glyoxylate
-
?
isocitrate
-
Candida albicans succinate + glyoxylate
-
?

Synonyms

Synonyms Comment Organism
ICL
-
Escherichia coli
ICL
-
Neurospora crassa
ICL
-
Acinetobacter calcoaceticus
ICL
-
Mycobacterium tuberculosis
ICL
-
Ricinus communis
ICL
-
Pyricularia grisea
ICL
-
Vogesella indigofera
ICL
-
Candida albicans