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Literature summary for 4.1.3.27 extracted from
- Zur Charakterisierung der Anthranilat-Synthetase bei Claviceps (1976), Biochem. Physiol. Pflanz., 169, 471-486.
No PubMed abstract available
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| chanoclavine | slight activation in presence of His | Claviceps sp. |  |
| elymoclavine | slight activation in presence of His | Claviceps sp. | |
| indoleacrylic acid | slight activation in presence of His | Claviceps sp. | |
| prephenic acid | slight activation in presence of His | Claviceps sp. | |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| Ba2+ | - |
Claviceps sp. | |
| Ca2+ | - |
Claviceps sp. | |
| Fe2+ | - |
Claviceps sp. | |
| Hg2+ | 0.005 mM HgCl2, complete inhibition | Claviceps sp. | |
| iodoacetamide | - |
Claviceps sp. | |
| L-Trp | - |
Claviceps sp. | |
| Pb2+ | - |
Claviceps sp. | |
| PCMB | 0.005 mM, complete inhibition | Claviceps sp. | |
| Zn2+ | 1 mM, 75% inhibition | Claviceps sp. | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.04 | - |
chorismate | - |
Claviceps sp. | |
| 4 | - |
Gln | - |
Claviceps sp. | |
| 8 | 9 | NH4+ | - |
Claviceps sp. | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Co2+ | - |
Claviceps sp. | |
| K+ | stimulates | Claviceps sp. | |
| Mg2+ | required | Claviceps sp. | |
| Mg2+ | Km: 0.4 mM | Claviceps sp. | |
| Mn2+ | - |
Claviceps sp. | |
| Na+ | stimulates | Claviceps sp. | |
| NH4+ | stimulates | Claviceps sp. | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Claviceps purpurea | - |
strain Pepty 695 and strain M5/95F | - |
| Claviceps sp. | - |
- |
- |
| Claviceps sp. SD58 | - |
- |
- |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| partial | Claviceps sp. |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| chorismate + L-Gln | - |
Claviceps purpurea | anthranilate + pyruvate + L-glutamate | - |
? | |
| chorismate + L-Gln | - |
Claviceps sp. | anthranilate + pyruvate + L-glutamate | - |
? | |
| chorismate + L-Gln | - |
Claviceps sp. SD58 | anthranilate + pyruvate + L-glutamate | - |
? | |
| chorismate + NH4+ | - |
Claviceps sp. | ? | - |
? | |
| chorismate + NH4+ | - |
Claviceps sp. SD58 | ? | - |
? | |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 7.8 | - |
Gln-dependent activity | Claviceps sp. |
| 8.6 | - |
NH4+-dependent activity | Claviceps sp. |
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