Literature summary for 4.2.1.1 extracted from

Ferraroni, M.; Tilli, S.; Briganti, F.; Chegwidden, W.R.; Supuran, C.T.; Wiebauer, K.E.; Tashian, R.E.; Scozzafava, A.
Crystal structure of a zinc-activated variant of human carbonic anhydrase I, CA I Michigan 1: Evidence for a second zinc binding site involving arginine coordination (2002), Biochemistry, 41, 6237-6244.

Search for more literature for 4.2.1.1

Cloned(Commentary)

Cloned (Comment)	Organism
cDNA transformed into Escherichia coli JM109	Homo sapiens

Crystallization (Commentary)

Crystallization (Comment)	Organism
crystals obtained using the hanging drop vapor diffusion method, isozyme CA I Michigan I, space group P2(1)2(1)2(1), with unit cell dimensions parameters a : 62.50 A, b : 72.13 A, c : 121.54 A, isozyme CA I Michigan 1-Zn(II)2, space group P2(1)2(1)2(1), with unit cell dimensions parameters a : 62.68 A, b : 71.36 A, c : 120.91A	Homo sapiens

Protein Variants

Protein Variants	Comment	Organism
H67R	site-directed mutagenesis, single point mutation in a critical region of the active site	Homo sapiens

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	zinc-activated variant	Homo sapiens

Molecular Weight [Da]

Molecular Weight [Da]	Molecular Weight Maximum [Da]	Comment	Organism
29000	-	1 * 29000	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Homo sapiens	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	P00915	-	-

Purification (Commentary)

Purification (Comment)	Organism
-	Homo sapiens

Source Tissue

Source Tissue	Comment	Organism	Textmining
placenta	-	Homo sapiens	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
4-nitrophenyl acetate + H2O	-	Homo sapiens	4-nitrophenol + acetate	-	r
H2CO3	-	Homo sapiens	CO2 + H2O	-	r

Subunits

Subunits	Comment	Organism
monomer	1 * 29000	Homo sapiens

Synonyms

Synonyms	Comment	Organism
CA I	-	Homo sapiens
carbonic anhydrase	-	Homo sapiens
carbonic anhydrase I (CA I) Michigan 1	-	Homo sapiens
human carbonic anhydrase I	-	Homo sapiens

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Release 2023.1 (January 2023)