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Literature summary for 4.2.1.1 extracted from
- Carbonic anhydrase inhibitors, interaction of boron derivatives with isozymes I and II: A new binding site for hydrophobic inhibitors at the entrance of the active site as shown by docking studies (2001), J. Enzyme Inhib., 16, 125-133.
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| cDNA expressed in Escherichia coli BL21 (DE3) | Homo sapiens |
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| 4-toluenesulfonamide | - |
Homo sapiens |  |
| dimethylsilyl para-toluenesulfonamidoborane | - |
Homo sapiens | |
| dimethylsilyl-diphenylaminoborane | - |
Homo sapiens | |
| dimethylsilyl-N-methyl-N-phenylaminoborane | - |
Homo sapiens | |
| dimethylsilylaminoborane | - |
Homo sapiens | |
| dimethylsilylboronic acid | - |
Homo sapiens | |
| dimethylsilylfluoroborane | - |
Homo sapiens | |
| dimethylsilylsulfonamidoborane | - |
Homo sapiens | |
| PH2BOH | - |
Homo sapiens | |
| sulfanilamide | - |
Homo sapiens | |
Metals/Ions
| Metals/Ions | Comment | Organism | Structure |
|---|---|---|---|
| Zn2+ | zinc-metalloenzyme | Homo sapiens | |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 4-nitrophenyl acetate + H2O | - |
Homo sapiens | 4-nitrophenol + acetate | - |
r | |
| H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| CA I | - |
Homo sapiens |
| CA II | - |
Homo sapiens |
| HCA | - |
Homo sapiens |
| human carbonic anhydrase | - |
Homo sapiens |
| human carbonic anhydrase isoenzyme I | - |
Homo sapiens |
| human carbonic anhydrase isoenzyme II | - |
Homo sapiens |
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Release 2023.1 (January 2023)
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