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Literature summary for 4.2.1.1 extracted from

  • Temperini, C.; Innocenti, A.; Mastrolorenzo, A.; Scozzafava, A.; Supuran, C.T.
    Carbonic anhydrase inhibitors. Interaction of the antiepileptic drug sulthiame with twelve mammalian isoforms: kinetic and X-ray crystallographic studies (2007), Bioorg. Med. Chem. Lett., 17, 4866-4872.
    View publication on PubMed

Crystallization (Commentary)

Crystallization (Comment) Organism
the hCA II-sulthiame complex is crystallized by cocrystallization procedures. High resolution crystal structure of the hCA II-sulthiame adduct Homo sapiens

Inhibitors

Inhibitors Comment Organism Structure
sulthiame isoenzyme hCA I; isoenzyme hCA II; isoenzyme hCA III; isoenzyme hCA IV; isoenzyme hCA IX; isoenzyme hCA VA; isoenzyme hCA VB; isoenzyme hCA VI; isoenzyme hCA VII; isoenzyme hCA XIV Homo sapiens
sulthiame isoenzyme mCA XIII Mus musculus

Organism

Organism UniProt Comment Textmining
Homo sapiens P00915
-
-
Homo sapiens P00918
-
-
Homo sapiens P07451
-
-
Homo sapiens P22748
-
-
Homo sapiens P23280
-
-
Homo sapiens P35218
-
-
Homo sapiens P43166
-
-
Homo sapiens Q16790
-
-
Homo sapiens Q9ULX7
-
-
Homo sapiens Q9Y2D0
-
-
Mus musculus Q9D6N1
-
-

Synonyms

Synonyms Comment Organism
hCA I
-
Homo sapiens
HCA II
-
Homo sapiens
hCA III
-
Homo sapiens
hCA IV
-
Homo sapiens
hCA IX
-
Homo sapiens
hCA VA
-
Homo sapiens
hCA VB
-
Homo sapiens
hCA VI
-
Homo sapiens
hCA VII
-
Homo sapiens
hCA XIV
-
Homo sapiens
mCA XIII
-
Mus musculus

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000006
-
sulthiame isoenzyme hCA VII Homo sapiens
0.000007
-
sulthiame isoenzyme hCA II Homo sapiens
0.000043
-
sulthiame isoenzyme hCA IX Homo sapiens
0.000081
-
sulthiame isoenzyme hCA VA Homo sapiens
0.000091
-
sulthiame isoenzyme hCA VB Homo sapiens
0.000095
-
sulthiame isoenzyme hCA IV Homo sapiens
0.000134
-
sulthiame isoenzyme hCA VI Homo sapiens
0.000374
-
sulthiame isoenzyme hCA I Homo sapiens
0.00145
-
sulthiame isoenzyme mCA XIII Mus musculus
0.00525
-
sulthiame isoenzyme hCA XIV Homo sapiens
0.63
-
sulthiame isoenzyme hCA III Homo sapiens