Inhibitors | Comment | Organism | Structure |
---|---|---|---|
acetazolamide | - |
Candida albicans | |
acetazolamide | i.e. 5-acetamido-1,3,4-thiadiazole-2-sulfonamide | Cryptococcus neoformans | |
azide | - |
Candida albicans | |
azide | - |
Cryptococcus neoformans | |
bromide | - |
Candida albicans | |
bromide | - |
Cryptococcus neoformans | |
Carbonate | potent inhibitor | Candida albicans | |
Carbonate | - |
Cryptococcus neoformans | |
chloride | - |
Candida albicans | |
chloride | - |
Cryptococcus neoformans | |
cyanide | potent inhibitor | Candida albicans | |
cyanide | weak inhibitor | Cryptococcus neoformans | |
fluoride | - |
Candida albicans | |
fluoride | - |
Cryptococcus neoformans | |
hydrogen carbonate | - |
Candida albicans | |
hydrogen carbonate | - |
Cryptococcus neoformans | |
hydrogen sulfide | - |
Candida albicans | |
hydrogen sulfide | best Can2 anion inhibitor | Cryptococcus neoformans | |
hydrogen sulfite | - |
Candida albicans | |
hydrogen sulfite | - |
Cryptococcus neoformans | |
Iodide | - |
Candida albicans | |
Iodide | worst Can2 anion inhibitor | Cryptococcus neoformans | |
isocyanide | - |
Candida albicans | |
isocyanide | - |
Cryptococcus neoformans | |
additional information | perchlorate is not an inhibitor in concentrations up to 200 mM | Candida albicans | |
additional information | Can2 is not inhibited by perchlorate | Cryptococcus neoformans | |
nitrate | - |
Candida albicans | |
nitrate | - |
Cryptococcus neoformans | |
nitrite | - |
Candida albicans | |
nitrite | - |
Cryptococcus neoformans | |
phenyl arsonic acid | weak Nce103 inhibitor | Candida albicans | |
phenyl arsonic acid | - |
Cryptococcus neoformans | |
phenyl boronic acid | weak Nce103 inhibitor | Candida albicans | |
phenyl boronic acid | - |
Cryptococcus neoformans | |
sulfamic acid | - |
Candida albicans | |
sulfamic acid | weak inhibitor | Cryptococcus neoformans | |
sulfamide | - |
Candida albicans | |
sulfamide | - |
Cryptococcus neoformans | |
sulfate | weak Nce103 inhibitor | Candida albicans | |
sulfate | - |
Cryptococcus neoformans | |
Thiocyanide | - |
Candida albicans | |
Thiocyanide | - |
Cryptococcus neoformans |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Cryptococcus neoformans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Candida albicans | H2CO3 | - |
r | |
CO2 + H2O | - |
Cryptococcus neoformans | H2CO3 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
beta-carbonic anhydrase | - |
Candida albicans |
beta-carbonic anhydrase | - |
Cryptococcus neoformans |
Can2 | - |
Cryptococcus neoformans |
Nce103 | - |
Candida albicans |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
390000 | - |
CO2 | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
800000 | - |
CO2 | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000105 | - |
acetazolamide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.000132 | - |
acetazolamide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.01 | - |
Carbonate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.011 | - |
cyanide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.3 | - |
sulfamide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.37 | - |
hydrogen sulfide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.52 | - |
azide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.53 | - |
nitrite | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.54 | - |
hydrogen sulfite | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.6 | - |
hydrogen sulfide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.6 | - |
Carbonate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.62 | - |
hydrogen carbonate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.65 | - |
Thiocyanide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.69 | - |
nitrate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.69 | - |
fluoride | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.7 | - |
sulfamic acid | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.71 | - |
hydrogen sulfite | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.73 | - |
azide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.75 | - |
hydrogen carbonate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.81 | - |
phenyl boronic acid | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.85 | - |
chloride | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.86 | - |
sulfate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.86 | - |
fluoride | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.87 | - |
phenyl arsonic acid | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.92 | - |
chloride | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.92 | - |
nitrate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.94 | - |
bromide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
0.94 | - |
Thiocyanide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.96 | - |
nitrite | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
0.99 | - |
sulfamide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
1 | - |
bromide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
1.01 | - |
isocyanide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
1.11 | - |
Iodide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
1.18 | - |
isocyanide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
1.4 | - |
Iodide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
8.22 | - |
sulfamic acid | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
13.56 | - |
cyanide | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Cryptococcus neoformans | |
14.15 | - |
sulfate | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
30.84 | - |
phenyl arsonic acid | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans | |
30.85 | - |
phenyl boronic acid | at 20°C, pH 8.3 in 20 mM Tris buffer and 20 mM NaClO4 | Candida albicans |