Inhibitors | Comment | Organism | Structure |
---|---|---|---|
2,3,4,5,6-pentafluoro-N-(2-sulfamoylphenyl)benzenesulfonamide | - |
Plasmodium falciparum | |
2,3,4,5,6-pentafluoro-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide | - |
Plasmodium falciparum | |
2,3,4,5,6-pentafluoro-N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]benzamide | - |
Plasmodium falciparum | |
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(2-sulfamoylphenyl)acetamide | - |
Plasmodium falciparum | |
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(3-sulfamoylphenyl)acetamide | - |
Plasmodium falciparum | |
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide | - |
Plasmodium falciparum | |
2-oxo-N-(2-sulfamoylphenyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
2-oxo-N-(3-sulfamoylphenyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
2-oxo-N-(4-sulfamoylbenzyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
2-oxo-N-(4-sulfamoylphenyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
2-[(diphenylcarbamoyl)amino]benzenesulfonamide | - |
Plasmodium falciparum | |
4-(3,4-dichlorophenylureido)thioureido-benzenesulfonamide | effective in vitro carbonic anhydrase inhibitor | Plasmodium falciparum | |
4-(3-[[(1E)-(1-methyl-1H-imidazol-2-yl)methylidene]amino]propyl)benzenesulfonamide | - |
Plasmodium falciparum | |
4-(carbamothioylamino)benzenesulfonamide | - |
Plasmodium falciparum | |
4-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)benzenesulfonamide | - |
Plasmodium falciparum | |
4-([[(1Z)-(2-chlorophenyl)methylidene]amino]methyl)benzenesulfonamide | - |
Plasmodium falciparum | |
4-([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)benzenesulfonamide | - |
Plasmodium falciparum | |
4-sulfamoyl-N-(4-sulfamoylphenyl)benzamide | - |
Plasmodium falciparum | |
4-[([(1Z)-[4-(dimethylamino)phenyl]methylidene]amino)methyl]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)methyl]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[2-[(2-oxo-2H-chromen-3-yl)carbonyl]hydrazino]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[2-[(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl]hydrazino]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[3-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)propyl]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[[(1Z)-(1-bromonaphthalen-2-yl)methylidene]amino]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[[(3,4-dichlorophenyl)carbamoyl]amino]benzenesulfonamide | - |
Plasmodium falciparum | |
4-[[(diphenylcarbamoyl)amino]methyl]benzenesulfonamide | - |
Plasmodium falciparum | |
5-[[(pentafluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide | - |
Plasmodium falciparum | |
5-[[(phenylcarbamoyl)carbamothioyl]amino]-1,3,4-thiadiazole-2-sulfonamide | - |
Plasmodium falciparum | |
acetazolamide | - |
Plasmodium falciparum | |
additional information | not inhibited by quinine, qinghausu, and chloroquine | Plasmodium falciparum | |
N-[(4-[[(4-sulfamoylphenyl)carbamothioyl]amino]phenyl)sulfonyl]acetamide | - |
Plasmodium falciparum | |
N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamide | - |
Plasmodium falciparum | |
N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-oxo-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
N-[4-[(aminooxy)sulfinyl]phenyl]-4-[(diphenylcarbamoyl)amino]benzenesulfonamide | - |
Plasmodium falciparum | |
N-[5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-yl]-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide | - |
Plasmodium falciparum |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Plasmodium falciparum | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
p-nitrophenyl acetate + H2O | - |
Plasmodium falciparum | p-nitrophenol + acetate | - |
? |
Synonyms | Comment | Organism |
---|---|---|
carbonic anhydrase | - |
Plasmodium falciparum |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.00018 | - |
4-(3,4-dichlorophenylureido)thioureido-benzenesulfonamide | - |
Plasmodium falciparum | |
0.000192 | - |
N-[5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-yl]-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide | - |
Plasmodium falciparum | |
0.00025 | - |
4-([[(1Z)-(2-chlorophenyl)methylidene]amino]methyl)benzenesulfonamide | - |
Plasmodium falciparum | |
0.000315 | - |
5-[[(phenylcarbamoyl)carbamothioyl]amino]-1,3,4-thiadiazole-2-sulfonamide | - |
Plasmodium falciparum | |
0.00097 | - |
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide | - |
Plasmodium falciparum | |
0.001436 | - |
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(2-sulfamoylphenyl)acetamide | - |
Plasmodium falciparum | |
0.001992 | - |
2-[(diphenylcarbamoyl)amino]benzenesulfonamide | - |
Plasmodium falciparum | |
0.002102 | - |
4-(carbamothioylamino)benzenesulfonamide | - |
Plasmodium falciparum | |
0.002519 | - |
N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamide | - |
Plasmodium falciparum | |
0.002583 | - |
5-[[(pentafluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide | - |
Plasmodium falciparum | |
0.002997 | - |
4-([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)benzenesulfonamide | - |
Plasmodium falciparum | |
0.003053 | - |
4-sulfamoyl-N-(4-sulfamoylphenyl)benzamide | - |
Plasmodium falciparum | |
0.003055 | - |
2,3,4,5,6-pentafluoro-N-(2-sulfamoylphenyl)benzenesulfonamide | - |
Plasmodium falciparum | |
0.003441 | - |
2,3,4,5,6-pentafluoro-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide | - |
Plasmodium falciparum | |
0.003506 | - |
4-[2-[(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl]hydrazino]benzenesulfonamide | - |
Plasmodium falciparum | |
0.004057 | - |
4-[2-[(2-oxo-2H-chromen-3-yl)carbonyl]hydrazino]benzenesulfonamide | - |
Plasmodium falciparum | |
0.004162 | - |
4-[[(1Z)-(1-bromonaphthalen-2-yl)methylidene]amino]benzenesulfonamide | - |
Plasmodium falciparum | |
0.004578 | - |
2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(3-sulfamoylphenyl)acetamide | - |
Plasmodium falciparum | |
0.004622 | - |
N-[(4-[[(4-sulfamoylphenyl)carbamothioyl]amino]phenyl)sulfonyl]acetamide | - |
Plasmodium falciparum | |
0.005048 | - |
2-oxo-N-(4-sulfamoylbenzyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
0.00558 | - |
4-[[(3,4-dichlorophenyl)carbamoyl]amino]benzenesulfonamide | - |
Plasmodium falciparum | |
0.005816 | - |
2-oxo-N-(4-sulfamoylphenyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
0.006867 | - |
2,3,4,5,6-pentafluoro-N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]benzamide | - |
Plasmodium falciparum | |
0.008392 | - |
4-[([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)methyl]benzenesulfonamide | - |
Plasmodium falciparum | |
0.009034 | - |
N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-oxo-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
0.01317 | - |
2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
0.01604 | - |
4-[[(diphenylcarbamoyl)amino]methyl]benzenesulfonamide | - |
Plasmodium falciparum | |
0.01652 | - |
N-[4-[(aminooxy)sulfinyl]phenyl]-4-[(diphenylcarbamoyl)amino]benzenesulfonamide | - |
Plasmodium falciparum | |
0.01851 | - |
2-oxo-N-(2-sulfamoylphenyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
0.02 | - |
acetazolamide | - |
Plasmodium falciparum | |
0.025 | - |
2-oxo-N-(3-sulfamoylphenyl)-2H-chromene-3-carboxamide | - |
Plasmodium falciparum | |
0.025 | - |
4-(3-[[(1E)-(1-methyl-1H-imidazol-2-yl)methylidene]amino]propyl)benzenesulfonamide | - |
Plasmodium falciparum | |
0.025 | - |
4-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)benzenesulfonamide | - |
Plasmodium falciparum | |
0.025 | - |
4-[([(1Z)-[4-(dimethylamino)phenyl]methylidene]amino)methyl]benzenesulfonamide | - |
Plasmodium falciparum | |
0.025 | - |
4-[3-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)propyl]benzenesulfonamide | - |
Plasmodium falciparum |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
0.000315 | - |
- |
Plasmodium falciparum | acetazolamide | |
0.001002 | - |
- |
Plasmodium falciparum | 4-(3,4-dichlorophenylureido)thioureido-benzenesulfonamide | |
0.003886 | - |
- |
Plasmodium falciparum | 4-([[(1Z)-(2-chlorophenyl)methylidene]amino]methyl)benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-oxo-2H-chromene-3-carboxamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2,3,4,5,6-pentafluoro-N-(2-sulfamoylphenyl)benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2,3,4,5,6-pentafluoro-N-(5-sulfamoyl-1,3,4-thiadiazol-2-yl)benzamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2,3,4,5,6-pentafluoro-N-[(2E)-3-methyl-5-sulfamoyl-1,3,4-thiadiazol-2(3H)-ylidene]benzamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(2-sulfamoylphenyl)acetamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(3-sulfamoylphenyl)acetamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-(7-methoxy-2-oxo-2H-chromen-4-yl)-N-(4-sulfamoylphenyl)acetamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-oxo-N-(2-sulfamoylphenyl)-2H-chromene-3-carboxamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-oxo-N-(3-sulfamoylphenyl)-2H-chromene-3-carboxamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-oxo-N-(4-sulfamoylbenzyl)-2H-chromene-3-carboxamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-oxo-N-(4-sulfamoylphenyl)-2H-chromene-3-carboxamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-oxo-N-[2-(4-sulfamoylphenyl)ethyl]-2H-chromene-3-carboxamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 2-[(diphenylcarbamoyl)amino]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-(3-[[(1E)-(1-methyl-1H-imidazol-2-yl)methylidene]amino]propyl)benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-(carbamothioylamino)benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-sulfamoyl-N-(4-sulfamoylphenyl)benzamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[([(1Z)-[4-(dimethylamino)phenyl]methylidene]amino)methyl]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[([[(diethyl-l5-azanylidyne)methyl]disulfanyl]amino)methyl]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[2-[(2-oxo-2H-chromen-3-yl)carbonyl]hydrazino]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[2-[(7-methoxy-2-oxo-2H-chromen-4-yl)acetyl]hydrazino]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[3-([(1E)-[4-(dimethylamino)phenyl]methylidene]amino)propyl]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[[(1Z)-(1-bromonaphthalen-2-yl)methylidene]amino]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[[(3,4-dichlorophenyl)carbamoyl]amino]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 4-[[(diphenylcarbamoyl)amino]methyl]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 5-[[(pentafluorophenyl)sulfonyl]amino]-1,3,4-thiadiazole-2-sulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | 5-[[(phenylcarbamoyl)carbamothioyl]amino]-1,3,4-thiadiazole-2-sulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | N-[(4-[[(4-sulfamoylphenyl)carbamothioyl]amino]phenyl)sulfonyl]acetamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | N-[2,4-disulfamoyl-5-(trifluoromethyl)phenyl]-2-(7-methoxy-2-oxo-2H-chromen-4-yl)acetamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | N-[4-[(aminooxy)sulfinyl]phenyl]-4-[(diphenylcarbamoyl)amino]benzenesulfonamide | |
0.05 | - |
IC50 above 0.05 mM | Plasmodium falciparum | N-[5-[(aminooxy)sulfinyl]-1,3,4-thiadiazol-2-yl]-1,1,2,2,3,3,4,4,5,5,6,6,7,7,8,8,8-heptadecafluorooctane-1-sulfonamide |