Cloned (Comment) | Organism |
---|---|
expressed in Escherichia coli BL21(DE3) cells using the baculovirus-insect cell expression system | Homo sapiens |
Crystallization (Comment) | Organism |
---|---|
isoform CA II, sitting drop vapor diffusion method, using 0.1 M sodium bicine, 0.2 M ammonium sulfate and 2 M sodium malonate | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
1,1,1-trifluoromethanesulfonamide | - |
Homo sapiens | |
1,1-dimethyl-4-(7-sulfamoyl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazol-3-yl)piperazin-1-ium iodide | - |
Homo sapiens | |
3-(4-methylpiperazin-1-yl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | - |
Homo sapiens | |
3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | - |
Homo sapiens | |
3-(methylsulfonyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | - |
Homo sapiens | |
3-(phenylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | - |
Homo sapiens | |
3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | - |
Homo sapiens | |
3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | - |
Homo sapiens | |
4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | - |
Homo sapiens | |
acetazolamide | - |
Homo sapiens | |
methazolamide | - |
Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | Q16790 | isozyme CA IX | - |
Purification (Comment) | Organism |
---|---|
Sepharose-IDA-Ni+2 column chromatography, S-Sepharose column chromatography, gel filtration | Homo sapiens |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
CO2 + H2O | - |
Homo sapiens | H2CO3 | - |
r |
Synonyms | Comment | Organism |
---|---|---|
CA I | isozyme | Homo sapiens |
CA II | isozyme | Homo sapiens |
CA IX | isozyme | Homo sapiens |
carbonic anhydrase | - |
Homo sapiens |
Temperature Stability Minimum [°C] | Temperature Stability Maximum [°C] | Comment | Organism |
---|---|---|---|
55 | 60 | the melting temperature is around 55°C without the addition of ligand, and shifts to 60°C or higher when the added ligand binds and stabilizes the protein | Homo sapiens |
Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000009 | - |
3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA II, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.000033 | - |
3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA II, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.000057 | - |
3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA II, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.00015 | - |
3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA I, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.00021 | - |
3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA I, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.00021 | - |
3-morpholin-4-yl-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA IX, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.00046 | - |
4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA II, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.00051 | - |
3-(methylsulfanyl)-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA IX, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.00066 | - |
3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA I, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.00072 | - |
4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA IX, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.001 | - |
3-chloro-4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA IX, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens | |
0.0021 | - |
4H-[1,2,3]thiadiazolo[3,4-a]benzimidazole-7-sulfonamide | isoform CA I, in 10 mM HEPES (pH 7.5), 0.1 M Na2SO4 | Homo sapiens |