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Literature summary for 4.2.1.1 extracted from
- In vitro inhibition of human carbonic anhydrase I and II isozymes with natural phenolic compounds (2011), Chem. Biol. Drug Des., 77, 494-499.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| acetazolamide | - |
Homo sapiens |  |
| catechin | a competitive inhibitor with 4-nitrophenylacetate as substrate | Homo sapiens | |
| curcumin | a competitive inhibitor with 4-nitrophenylacetate as substrate | Homo sapiens | |
| dobutamin | a competitive inhibitor with 4-nitrophenylacetate as substrate | Homo sapiens | |
| additional information | some natural phenols show effective hCA II inhibitory effects, in the same range as the clinically used sulfonamide acetazolamide, and might be used as leads for generating enzyme inhibitors possibly targeting other CA isozymes | Homo sapiens | |
| resveratrol | a competitive inhibitor with 4-nitrophenylacetate as substrate | Homo sapiens | |
| silymarin | a competitive inhibitor with 4-nitrophenylacetate as substrate | Homo sapiens | |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cytosol | isozymes carbonic anhydrase I and II | Homo sapiens | 5829 | - |
Natural Substrates/ Products (Substrates)
| Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | Homo sapiens | - |
CO2 + H2O | - |
r | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | - |
isozymes carbonic anhydrase I and II | - |
Purification (Commentary)
| Purification (Comment) | Organism |
|---|---|
| native hCA I and hCA II from erythrocytes by aniline-sulfanylamide affinity chromatography | Homo sapiens |
Source Tissue
| Source Tissue | Comment | Organism | Textmining |
|---|---|---|---|
| erythrocyte | - |
Homo sapiens | - |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| H2CO3 | - |
Homo sapiens | CO2 + H2O | - |
r | |
| additional information | the enzyme shows esterase assay with 4-nitrophenyl acetate as substrate | Homo sapiens | ? | - |
? | |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| carbonic anhydrase I | - |
Homo sapiens |
| carbonic anhydrase II | - |
Homo sapiens |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| additional information | - |
esterase activity assay at 25°C | Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| additional information | - |
esterase activity assay at pH 7.4 | Homo sapiens |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | Ki values for natural phenols with isozymes hCA I and hCA II in the esterase activity assay, overview | Homo sapiens |
IC50 Value
| IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
|---|---|---|---|---|---|
| additional information | - |
IC50 values for natural phenols with isozymes hCA I and hCA II in the esterase activity assay, overview | Homo sapiens | additional information |
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