Literature summary for 4.2.1.1 extracted from

Karacan, M.S.; Rodionova, M.V.; Tunc, T.; Venedik, K.B.; Mamas, S.; Shitov, A.V.; Zharmukhamedov, S.K.; Klimov, V.V.; Karacan, N.; Allakhverdiev, S.I.
Characterization of nineteen antimony(III) complexes as potent inhibitors of photosystem II, carbonic anhydrase, and glutathione reductase (2016), Photosynth. Res., 130, 167-182 .

Inhibitors

Inhibitors	Comment	Organism
1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyridin-1-ium)	29.9% inhibition of CO2 hydration reaction after 30 min	Bos taurus
1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyridin-1-ium)	31.6% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium)	57.6% inhibition of CO2 hydration reaction after 30 min	Bos taurus
1,1'-(tribromo-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium)	16.3% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
1,1'-(trichloro-lambda5-stibanediyl)bis(2-amino-4,6-dimethoxy-5-sulfanylpyrimidin-1-ium)	99.3% inhibition of CO2 hydration reaction after 30 min	Bos taurus
1,1'-(trichloro-lambda5-stibanediyl)bis(2-amino-4,6-dimethoxy-5-sulfanylpyrimidin-1-ium)	64.8% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyridin-1-ium)	49.2% inhibition of CO2 hydration reaction after 30 min	Bos taurus
1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyridin-1-ium)	9.4% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium)	98.4% inhibition of CO2 hydration reaction after 30 min	Bos taurus
1,1'-(trichloro-lambda5-stibanediyl)bis(2-aminopyrimidin-1-ium)	90.2% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
1,1'-(trichloro-lambda5-stibanediyl)bis[2-amino-4,6-dimethoxy-5-[(1H-tetrazol-5-yl)sulfanyl]pyrimidin-1-ium]	14.3% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
12,12,12-tribromo-7-oxo-6,7a,8,9,10,12-hexahydro-7H-12lambda5-pyrrolo[1',2':1,7][1,3,5,2]triazastibepino[4,3-b][1,3]benzothiazol-13-ium	92.3% inhibition of CO2 hydration reaction after 30 min	Bos taurus
12,12,12-tribromo-7-oxo-6,7a,8,9,10,12-hexahydro-7H-12lambda5-pyrrolo[1',2':1,7][1,3,5,2]triazastibepino[4,3-b][1,3]benzothiazol-13-ium	11.1% inhibition of CO2 hydration reaction after 30 min; 18.4% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
2-[[(5-chlorothiophen-2-yl)(hydroxy)methyl]amino]-1-(trichloro[2-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]pyrimidin-1-ium-1-yl]-lambda5-stibanyl)pyrimidin-1-ium	18.7% inhibition of CO2 hydration reaction after 30 min	Bos taurus
2-[[(5-chlorothiophen-2-yl)(hydroxy)methyl]amino]-1-(trichloro[2-[2-(5-chlorothiophen-2-yl)-2-oxoethyl]pyrimidin-1-ium-1-yl]-lambda5-stibanyl)pyrimidin-1-ium	62.5% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
3-amino-1,1,1-tribromo-4,5-dihydro-1H-1lambda5-[1,3,5,2]triazastibinino[1,6-a]benzimidazol-10-ium	35% inhibition of CO2 hydration reaction after 30 min	Bos taurus
3-amino-1,1,1-trichloro-4,5-dihydro-1H-1lambda5-[1,3,5,2]triazastibinino[1,6-a]benzimidazol-10-ium	10.0% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
5,5,5-tribromo-1,2,3,7,8,9,9a,11,16,17a-decahydro-5H-5lambda5-dipyrrolo[2,1-c:1',2'-f][1,4,6,9,5]benzotetraazastibacycloundecine-10,17-dione	83.9% inhibition of CO2 hydration reaction after 30 min	Bos taurus
5,5,5-tribromo-1,2,3,7,8,9,9a,11,16,17a-decahydro-5H-5lambda5-dipyrrolo[2,1-c:1',2'-f][1,4,6,9,5]benzotetraazastibacycloundecine-10,17-dione	9.9% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
6,6,6-trichloro-11-oxo-8,9,10,10a,11,12-hexahydro-6H-6lambda5-pyrimido[1,2-c]pyrrolo[2,1-g][1,3,5,2]triazastibepin-5-ium	31.0% inhibition of CO2 hydration reaction after 30 min	Bos taurus
6,6,6-trichloro-11-oxo-8,9,10,10a,11,12-hexahydro-6H-6lambda5-pyrimido[1,2-c]pyrrolo[2,1-g][1,3,5,2]triazastibepin-5-ium	25.1% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
6-chloro-6,6-dimethyl-12-oxo-6,8,9,10,11,11a,12,13-octahydro-6lambda5-pyrido[2,1-g]pyrimido[1,2-c][1,3,5,2]triazastibepin-5-ium	99.3% inhibition of CO2 hydration reaction after 30 min	Bos taurus
6-chloro-6,6-dimethyl-12-oxo-6,8,9,10,11,11a,12,13-octahydro-6lambda5-pyrido[2,1-g]pyrimido[1,2-c][1,3,5,2]triazastibepin-5-ium	22.9% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
dibenzyl N',N'''-(tribromo-lambda5-stibanediyl)biscarbamimidothioate	36.0% inhibition of CO2 hydration reaction after 30 min	Bos taurus
dibenzyl N',N'''-(trichloro-lambda5-stibanediyl)biscarbamimidothioate	26.7% inhibition of CO2 hydration reaction after 30 min	Bos taurus
dibenzyl N',N'''-(trichloro-lambda5-stibanediyl)biscarbamimidothioate	54.4% inhibition of CO2 hydration reaction after 30 min	Pisum sativum
additional information	antimony(III) complexes inhibit alpha-carbonic anhydrase isozyme II from bovine erythrocytes. No inhibition by 5	Bos taurus
additional information	antimony(III) complexes inhibit glutathione reductase activity of chloroplast, and a number of them also exhibit good inhibitory efficiency against the photosynthetic and carbonic anhydrase activity of Pisum sativum photosystem II	Pisum sativum

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
chloroplast	-	Pisum sativum	9507	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Zn2+	required, metalloenzyme	Bos taurus
Zn2+	required, metalloenzyme	Pisum sativum

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
H2CO3	Bos taurus	-	CO2 + H2O	-	r
H2CO3	Pisum sativum	-	CO2 + H2O	-	r

Organism

Organism	UniProt	Comment	Textmining
Bos taurus	P00921	-	-
Pisum sativum	P17067	-	-

Source Tissue

Source Tissue	Comment	Organism	Textmining
commercial preparation	-	Bos taurus	-
erythrocyte	-	Bos taurus	-
leaf	-	Pisum sativum	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
H2CO3	-	Bos taurus	CO2 + H2O	-	r
H2CO3	-	Pisum sativum	CO2 + H2O	-	r

Synonyms

Synonyms	Comment	Organism
alpha-CA	-	Bos taurus
alpha-carbonic anhydrase isozyme II	-	Bos taurus
CAA	-	Pisum sativum