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Literature summary for 4.2.1.113 extracted from

  • Pulaganti, M.; Banaganapalli, B.; Mulakayala, C.; Chitta, S.; Anuradha, C.
    Molecular modeling and docking studies of O-succinylbenzoate synthase of M. tuberculosis - a potential target for antituberculosis drug design (2014), Appl. Biochem. Biotechnol., 172, 1407-1432 .
    View publication on PubMed
Search for more literature for 4.2.1.113

Application

Application Comment Organism
drug development the enzyme is one of the major potential drug targets for Mycobacterium tuberculosis Mycobacterium tuberculosis

Inhibitors

Inhibitors Comment Organism Structure
additional information ligand docking interactions analysis, potential of 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate substrate (SHCHC) derivatives as competitive enzyme inhibitors, overview Mycobacterium tuberculosis

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis
-
 2-succinylbenzoate + H2O
-
 ?
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate Mycobacterium tuberculosis ATCC 25618 / H37Rv
-
 2-succinylbenzoate + H2O
-
 ?

Organism

Organism UniProt Comment Textmining
Mycobacterium tuberculosis P9WJP3
-
-
Mycobacterium tuberculosis ATCC 25618 / H37Rv P9WJP3
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis 2-succinylbenzoate + H2O
-
 ?
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate the enzyme converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate via an elimination of water. The reaction likely proceeds by a mechanism similar to those employed by other members of the enolase superfamily with initial abstraction of the R-proton of the carboxylic acid and stabilization of the resulting enolic intermediate Mycobacterium tuberculosis 2-succinylbenzoate + H2O
-
 ?
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate
-
 Mycobacterium tuberculosis ATCC 25618 / H37Rv 2-succinylbenzoate + H2O
-
 ?
(1R,6R)-6-hydroxy-2-succinylcyclohexa-2,4-diene-1-carboxylate the enzyme converts 2-succinyl-6-hydroxy-2,4-cyclohexadiene-1-carboxylate (SHCHC) to 4-(2'-carboxyphenyl)-4-oxobutyrate via an elimination of water. The reaction likely proceeds by a mechanism similar to those employed by other members of the enolase superfamily with initial abstraction of the R-proton of the carboxylic acid and stabilization of the resulting enolic intermediate Mycobacterium tuberculosis ATCC 25618 / H37Rv 2-succinylbenzoate + H2O
-
 ?

Synonyms

Synonyms Comment Organism
Mtb-OSBS
-
 Mycobacterium tuberculosis
OSBS
-
 Mycobacterium tuberculosis

General Information

General Information Comment Organism
metabolism O-succinylbenzoate synthase plays a major role in the shikimate pathway Mycobacterium tuberculosis
additional information molecular modeling and docking study of O-succinylbenzoate synthase of Mycobacterium tuberculosis, overview. A three-dimensional structure model of Mtb-OSBS is built using structure coordinates of Thermobifida fusca. Residues Lys108, Asn140, Asp138, Lys110, Glu189, Ser236, Asp188, Arg27, Tyr52, and Ser237 are highly conserved and may play a vital role as active residues Mycobacterium tuberculosis
physiological function O-succinylbenzoate synthase is an important enzyme in the biosynthesis of menaquinone, ubiquinone, and terpenoid quinone in Mycobacterium tuberculosis Mycobacterium tuberculosis