Crystallization (Comment) | Organism |
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structure determination. The eukaryotic hydratase 2 has a complete hot dog fold only in its C-domain, whereas the N-domain lacks a long central alpha-helix, thus creating space for bulkier substrates in the binding pocket. The hydrogen bonding network of the active site of 2-enoyl-CoA hydratase 2 resembles the active site geometry of mitochondrial (S)-specific 2-enoyl-CoA hydratase 1, although in a mirror image fashion | Candida tropicalis |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E)-2-enoyl-CoA + H2O | Candida tropicalis | 2-enoyl-CoA hydratase 2 is a part of multifunctional enzyme type 2, hydrates trans-2-enoyl-CoA to 3-hydroxyacyl-CoA as a key enzyme in the (3R)-hydroxy-dependent route of peroxisomal beta-oxidation of fatty acids | (3R)-3-hydroxyacyl-CoA | - |
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Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida tropicalis | P22414 | 2-enoyl-CoA hydratase 2 is a part of multifunctional enzyme type 2 | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(2E)-2-enoyl-CoA + H2O | 2-enoyl-CoA hydratase 2 is a part of multifunctional enzyme type 2, hydrates trans-2-enoyl-CoA to 3-hydroxyacyl-CoA as a key enzyme in the (3R)-hydroxy-dependent route of peroxisomal beta-oxidation of fatty acids | Candida tropicalis | (3R)-3-hydroxyacyl-CoA | - |
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Synonyms | Comment | Organism |
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2-enoyl-CoA hydratase 2 | is a part of multifunctional enzyme type 2 | Candida tropicalis |