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Literature summary for 4.2.1.19 extracted from

  • Glaser, R.D.; Houston, L.L.
    Subunit structure and photooxidation of yeast imidazoleglycerolphosphate dehydratase (1974), Biochemistry, 13, 5145-5152.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
2-mercaptoethanol activation Saccharomyces cerevisiae
cysteine activation Saccharomyces cerevisiae
mercaptoethylamine activation Saccharomyces cerevisiae

General Stability

General Stability Organism
Mg2+, Mn2+, glycerol, dithiothreitol do not stablilize Saccharomyces cerevisiae

Inhibitors

Inhibitors Comment Organism Structure
3-Amino-1,2,4-triazole
-
Saccharomyces cerevisiae
additional information not inhibited by histidinol phosphate, histidinol, histidine Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.54
-
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ Km: 0.0076 mM Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
35000
-
x * 35000, SDS-PAGE Saccharomyces cerevisiae
290000
-
gel filtration Saccharomyces cerevisiae
300000
-
gel electrophoresis Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Oxidation Stability

Oxidation Stability Organism
photooxidation in presence of Rose Bengal Saccharomyces cerevisiae

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Reaction

Reaction Comment Organism Reaction ID
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O energy of activation 15900 cal/mol Saccharomyces cerevisiae

Specific Activity [micromol/min/mg]

Specific Activity Minimum [┬Ámol/min/mg] Specific Activity Maximum [┬Ámol/min/mg] Comment Organism
0.31
-
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
-
Saccharomyces cerevisiae 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
-
?

Subunits

Subunits Comment Organism
polymer x * 35000, SDS-PAGE Saccharomyces cerevisiae

Temperature Stability [┬░C]

Temperature Stability Minimum [┬░C] Temperature Stability Maximum [┬░C] Comment Organism
54
-
60 min stable Saccharomyces cerevisiae