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Literature summary for 4.2.1.19 extracted from

  • Brady, D.R.; Houston, L.L.
    Some properties of the catalytic sites of imidazoleglycerol phosphate dehydratase-histidinol phosphate phosphatase, a bifunctional enzyme from Salmonella typhimurium (1973), J. Biol. Chem., 248, 2588-2592.
    View publication on PubMed
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General Stability

General Stability Organism
Mn2+ stabilizes Salmonella enterica subsp. enterica serovar Typhimurium

Inhibitors

Inhibitors Comment Organism Structure
3-Amino-1,2,4-triazole
-
 Salmonella enterica subsp. enterica serovar Typhimurium
phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium
Zn2+
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ Km: 0.0073 mM Salmonella enterica subsp. enterica serovar Typhimurium

Organism

Organism UniProt Comment Textmining
Salmonella enterica subsp. enterica serovar Typhimurium
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Salmonella enterica subsp. enterica serovar Typhimurium

Reaction

Reaction Comment Organism Reaction ID
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate = 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O energy of activation 14700 cal/mol Salmonella enterica subsp. enterica serovar Typhimurium
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
-
 Salmonella enterica subsp. enterica serovar Typhimurium 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
-
 ?

Temperature Stability [°C]

Temperature Stability Minimum [°C] Temperature Stability Maximum [°C] Comment Organism
54
-
 16 min, stable Salmonella enterica subsp. enterica serovar Typhimurium

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
7.5
-
-
 Salmonella enterica subsp. enterica serovar Typhimurium