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Literature summary for 4.2.1.19 extracted from

  • Hawkes, T.R.; Thomas, P.G.; Edwards, L.S.; Rayner, S.J.; Wilkinson, K.W.
    Purification and characterization of the imidazoleglycerol-phosphate dehydratase of Saccharomyces cerevisiae from recombinant Escherichia coli (1995), Biochem. J., 306, 385-397.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
3-Amino-1,2,4-triazole Ki: 0.12 mM Saccharomyces cerevisiae

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.1
-
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
-
Saccharomyces cerevisiae

Metals/Ions

Metals/Ions Comment Organism Structure
Mn2+ essential for assembly of subunits Saccharomyces cerevisiae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
70000
-
trimeric enzyme in absence of Mn2+, gel filtration Saccharomyces cerevisiae
500000
-
polymeric enzyme in presence of Mn2+, gel filtration Saccharomyces cerevisiae
23833
-
x * 23833, light scattering Saccharomyces cerevisiae

Organism

Organism UniProt Comment Textmining
Saccharomyces cerevisiae
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
Saccharomyces cerevisiae

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
D-erythro-1-(imidazol-4-yl)glycerol 3-phosphate
-
Saccharomyces cerevisiae 3-(imidazol-4-yl)-2-oxopropyl phosphate + H2O
-
?

Subunits

Subunits Comment Organism
polymer x * 23833, light scattering Saccharomyces cerevisiae