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Literature summary for 4.2.1.22 extracted from

  • Braunstein, A.E.; Goryachenkova, E.V.
    The beta-replacement-specific pyridoxal-P-dependent lyases (1984), Adv. Enzymol. Relat. Areas Mol. Biol., 56, 1-89.
    View publication on PubMed
Search for more literature for 4.2.1.22

General Stability

General Stability Organism
2-mercaptoethanol stabilizes Homo sapiens
2-mercaptoethanol stabilizes Rattus norvegicus
high protein concentration stabilizes Homo sapiens
high protein concentration stabilizes Rattus norvegicus
lyophilization inactivates Homo sapiens
lyophilization inactivates Rattus norvegicus

Inhibitors

Inhibitors Comment Organism Structure
aminooxyacetic acid
-
 Homo sapiens
aminooxyacetic acid
-
 Rattus norvegicus
hydroxylamine
-
 Homo sapiens
hydroxylamine
-
 Rattus norvegicus

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.59
-
 homocysteine
-
 Homo sapiens
1.15
-
 L-Ser
-
 Homo sapiens
8
-
 L-Ser
-
 Rattus norvegicus
18
-
 homocysteine
-
 Rattus norvegicus
24
-
 2-mercaptoethanol
-
 Rattus norvegicus
36
-
 L-Cys cosubstrate 2-mercaptoethanol Rattus norvegicus

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-Serine + homocysteine Gallus gallus
-
 ?
-
 ?
L-Serine + homocysteine Homo sapiens
-
 ?
-
 ?
L-Serine + homocysteine Rattus norvegicus
-
 ?
-
 ?

Organism

Organism UniProt Comment Textmining
Gallus gallus
-
-
-
Homo sapiens
-
-
-
Rattus norvegicus
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
liver
-
 Gallus gallus
-
liver
-
 Homo sapiens
-
liver
-
 Rattus norvegicus
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-Cysteine + 2-mercaptoethanol
-
 Rattus norvegicus HOOC-CH(NH2)-CH2-S-CH2-CH2OH + H2S
-
 ?
L-Serine + homocysteine
-
 Gallus gallus Cystathionine + H2O
-
 ?
L-Serine + homocysteine
-
 Homo sapiens Cystathionine + H2O
-
 ?
L-Serine + homocysteine
-
 Rattus norvegicus Cystathionine + H2O
-
 ?
L-Serine + homocysteine
-
 Gallus gallus ?
-
 ?
L-Serine + homocysteine
-
 Homo sapiens ?
-
 ?
L-Serine + homocysteine
-
 Rattus norvegicus ?
-
 ?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
8.4 9
-
 Homo sapiens

Cofactor

Cofactor Comment Organism Structure
pyridoxal 5'-phosphate requirement Homo sapiens
pyridoxal 5'-phosphate requirement Rattus norvegicus