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Literature summary for 4.2.1.28 extracted from

  • Abeles, R.H.
    Dehydrations requiring vitamin B12 coenzyme (1971), The Enzymes, 3rd Ed. (Boyer, P. D. , ed. ), 5, 481-497.
No PubMed abstract available
Search for more literature for 4.2.1.28

Inhibitors

Inhibitors Comment Organism Structure
adenosylcobalamin with e-propionamide group converted to carboxylic acid, inactivation during catalytic process, analogues inhibit if added prior to coenzyme Klebsiella pneumoniae

Molecular Weight [Da]

Molecular Weight [Da] Molecular Weight Maximum [Da] Comment Organism
220000 240000 gel filtration, sedimentation equilibrium of cell-free extracts Klebsiella pneumoniae

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycerol Klebsiella pneumoniae first step of anaerobic fermentation ?
-
 ?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
 formerly Aerobacter aerogenes
-

Purification (Commentary)

Purification (Comment) Organism
-
 Klebsiella pneumoniae

Reaction

Reaction Comment Organism Reaction ID
propane-1,2-diol = propanal + H2O mechanism: group migration involved, stereospecificity: replacement of C2-OH-group proceeds with inversion of configuration of both isomers, mechanism of hydrogen transfer, role of cobalt: dissociation of C-Co bond of the coenzyme and Co-binding to substrate Klebsiella pneumoniae
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
1,2-propanediol
-
 Klebsiella pneumoniae propanal
-
 ?
glycerol first step of anaerobic fermentation Klebsiella pneumoniae ?
-
 ?

Cofactor

Cofactor Comment Organism Structure
cobamide role during catalysis: dissociation of C-Co bond of the coenzyme and Co-binding to substrate, effect of analogues, one binding site per enzyme molecule Klebsiella pneumoniae