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Literature summary for 4.2.1.28 extracted from
- Inactivation of dioldehydrase in the presence of a coenzyme-B12 analog (1980), Arch. Biochem. Biophys., 203, 174-180.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| adenosylcobalamin | analogue where e-propionamide group is converted to carboxylic acid inactivates complex, forms hydroxycobalamine derivative, leaves apoenzyme intact, which indicates that inactivation occurs from one of the intermediates of the normal reaction, mechanism of inactivation | Klebsiella pneumoniae |  |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Klebsiella pneumoniae | - |
- |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| 1,2-propanediol | - |
Klebsiella pneumoniae | propanal | - |
? | |
Cofactor
| Cofactor | Comment | Organism | Structure |
|---|---|---|---|
| cobamide | importance of apoenzyme tertiary structure for coenzyme-substrate interaction | Klebsiella pneumoniae | |
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Release 2023.1 (January 2023)
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