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Literature summary for 4.2.1.3 extracted from

  • Zheng, W.; Ren, S.; Graziano, J.H.
    Manganese inhibits mitochondrial aconitase: a mechanism of manganese neurotoxicity (1998), Brain Res., 799, 334-342.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.1.3

Localization

Localization Comment Organism GeneOntology No. Textmining
mitochondrion
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 Rattus norvegicus 5739
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Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Rattus norvegicus Mn2+ exposure leads to a region-specific alteration in total aconitase: 48.5% reduction of the enzyme activity in frontal cortex, 33.7% in striatum and 20.6% in substantia nigra. This leads to the disruption of mitochondrial energy production and cellular Fe metabolism in the brain ?
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 ?

Organism

Organism UniProt Comment Textmining
Rattus norvegicus
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-
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Source Tissue

Source Tissue Comment Organism Textmining
brain
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 Rattus norvegicus
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Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
cis-aconitate + H2O
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 Rattus norvegicus isocitrate
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 ?
additional information Mn2+ exposure leads to a region-specific alteration in total aconitase: 48.5% reduction of the enzyme activity in frontal cortex, 33.7% in striatum and 20.6% in substantia nigra. This leads to the disruption of mitochondrial energy production and cellular Fe metabolism in the brain Rattus norvegicus ?
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 ?