Literature summary for 4.2.1.3 extracted from

Dupuy, J.; Darnault, C.; Brazzolotto, X.; Kuehn, L.C.; Moulis, J.M.; Volbeda, A.; Fontecilla-Camps, J.C.
Crystallization and preliminary x-ray diffraction data for the aconitase form of human iron-regulatory protein 1 (2005), Acta Crystallogr. Sect. F, F61, 482-485.

Search for more literature for 4.2.1.3

Crystallization (Commentary)

Crystallization (Comment)	Organism
recombinant enzyme, hanging-drop vapour-diffusion method. An X-ray fluorescence measurement performed on a gold-derivative crystal shows the unexpected presence of zinc, in addition to gold and iron	Homo sapiens

Localization

Localization	Comment	Organism	GeneOntology No.	Textmining
cytoplasm	IRP1	Homo sapiens	5737	-

Metals/Ions

Metals/Ions	Comment	Organism	Structure
Fe	IRP1 binds a [4Fe-4S] cluster	Homo sapiens
Zn	an X-ray fluorescence measurement performed on a gold-derivative crystal shows the unexpected presence of zinc, in addition to gold and iron	Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
additional information	Homo sapiens	IRP1 functions as a cytoplasmic aconitase. It may provide a link between citrate and iron metabolism and may be involved in oxidative stress response	?	-	?

Organism

Organism	UniProt	Comment	Textmining
Homo sapiens	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
additional information	IRP1 functions as a cytoplasmic aconitase. It may provide a link between citrate and iron metabolism and may be involved in oxidative stress response	Homo sapiens	?	-	?

Synonyms

Synonyms	Comment	Organism
iron-regulatory protein 1	-	Homo sapiens
IRP1	-	Homo sapiens

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Release 2023.1 (January 2023)