Activating Compound | Comment | Organism | Structure |
---|---|---|---|
additional information | acetyl-CoA-driven acetylation leads to about 45% activation. The increase in activity is a result of increased maximal velocity | Mus musculus |
Application | Comment | Organism |
---|---|---|
medicine | a high fat diet (60% kcal from fat) shows significantly increased mitochondrial aconitase activity without changes in protein level and produces increased aconitase acetylation at multiple sites | Mus musculus |
Crystallization (Comment) | Organism |
---|---|
molecular modeling suggests acetylation at K144 may perturb the tertiary structure of the enzyme | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | - |
Mus musculus | 5739 | - |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q99KI0 | - |
- |
Posttranslational Modification | Comment | Organism |
---|---|---|
acetylation | in vitro chemical acetylation with either acetic anhydride or acetyl-CoA results in increased aconitase activity that is reversed with SIRT3 treatment. Lysine residues K31, K138, K144, K401, K549, K689, K700, K701, and K723 represent the most responsive sites. A high fat diet (60% kcal from fat) also shows significantly increased mitochondrial aconitase activity without changes in protein level and produces increased aconitase acetylation at multiple sites | Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | - |
Mus musculus | - |
Synonyms | Comment | Organism |
---|---|---|
Aco2 | - |
Mus musculus |