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Literature summary for 4.2.1.30 extracted from

  • Smiley, K.L.; Sobolov, M.
    A cobamide-requiring glycerol dehydrase from an acrolein-forming Lactobacillus (1962), Arch. Biochem. Biophys., 97, 538-543.
    View publication on PubMed

Activating Compound

Activating Compound Comment Organism Structure
adenylcobamide activates Lactobacillus sp.
additional information
-
Klebsiella pneumoniae
additional information
-
Lactobacillus sp.
NH4+
-
Klebsiella pneumoniae
NH4+ required, most active univalent cation Lactobacillus sp.

Inhibitors

Inhibitors Comment Organism Structure
CN- KCN, pH 6.0, slowly inactivates Lactobacillus sp.
cyanocobalamin quite inhibitory to enzyme activity if it is added to the apoenzyme before the 5,6-dimethylbenzimidazolylcobamide Lactobacillus sp.
hydroxycobalamin
-
Lactobacillus sp.
additional information
-
Klebsiella pneumoniae
additional information
-
Lactobacillus sp.
Na+
-
Klebsiella pneumoniae
Na+
-
Lactobacillus sp.
p-chloromercuribenzoate
-
Klebsiella pneumoniae
p-chloromercuribenzoate 2,3-dimercaptopropanol, glutathione and cysteine protect Lactobacillus sp.
phenyl mercuri acetate
-
Lactobacillus sp.

Metals/Ions

Metals/Ions Comment Organism Structure
K+ required Klebsiella pneumoniae
K+ required Lactobacillus sp.
K+ 80-90% as active as NH4+ Lactobacillus sp.
Rb+ required, 80-90% as active as NH4+ Klebsiella pneumoniae
Rb+ required, 80-90% as active as NH4+ Lactobacillus sp.

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
glycerol Klebsiella pneumoniae
-
?
-
?
glycerol Lactobacillus sp.
-
?
-
?
glycerol Lactobacillus sp. 208-A
-
?
-
?

Organism

Organism UniProt Comment Textmining
Klebsiella pneumoniae
-
-
-
Lactobacillus sp.
-
208-A
-
Lactobacillus sp. 208-A
-
208-A
-

Specific Activity [micromol/min/mg]

Specific Activity Minimum [µmol/min/mg] Specific Activity Maximum [µmol/min/mg] Comment Organism
additional information
-
-
Klebsiella pneumoniae
additional information
-
-
Lactobacillus sp.

Storage Stability

Storage Stability Organism
-20°C, soluble enzyme is stable for at least 2 weeks Lactobacillus sp.
4°C, soluble enzyme loses 25% of activity in 3 days Lactobacillus sp.

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
glycerol
-
Klebsiella pneumoniae 3-hydroxypropanal + H2O beta-hydroxypropionaldehyde ?
glycerol
-
Lactobacillus sp. 3-hydroxypropanal + H2O beta-hydroxypropionaldehyde ?
glycerol
-
Lactobacillus sp. 208-A 3-hydroxypropanal + H2O beta-hydroxypropionaldehyde ?
glycerol
-
Klebsiella pneumoniae ?
-
?
glycerol
-
Lactobacillus sp. ?
-
?
glycerol
-
Lactobacillus sp. 208-A ?
-
?

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
5.8 6
-
Lactobacillus sp.
8
-
-
Klebsiella pneumoniae

Cofactor

Cofactor Comment Organism Structure
5,6-Dimethylbenzimidazolylcobamide coenzyme required Klebsiella pneumoniae
5,6-Dimethylbenzimidazolylcobamide coenzyme required Lactobacillus sp.