Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | trimethyl trans-homoaconitate, trimethyl (1E)1,2-epoxy-butane-1,2,4-tricarboxylate, dimethyl (2S,3R)-2-hydroxy-3-propylsuccinate, dimethyl (2S,3R)-2-hydroxy-3-butylsuccinate, dimethyl (2S,3R)-2-hydroxy-3-allylsuccinate, dimethyl (2R,3S)-2-fluoro-3-propylsuccinate, dimethyl (2R,3S)-2-fluoro-3-butylsuccinate, dimethyl (2R,3S)-2-fluoro-3-allylsuccinate, trimethyl (2R,3S)-2-fluoro-2-deoxyhomoisocitrate, dipotassium (2R,3S)-2-fluoro-3-allylsuccinate, and tripotassium (2R,3S)-2-fluoro-2-deoxyhomoisocitrate have no effect on enzyme activity at concentrations up to 10 mM | Candida albicans | |
trans-homoaconitate | - |
Candida albicans | |
tripotassium (1E)1,2-epoxy-butane-1,2,4-tricarboxylate | - |
Candida albicans |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1.5 | - |
(R)-homocitrate | in 50 mM Tris-HCl (pH 8.5), 50 mM KCl, 5 mM MgCl2, 20 mM dithiothreitol, at 20°C | Candida albicans |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate | Candida albicans | - |
(Z)-but-1-ene-1,2,4-tricarboxylate + H2O | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Candida albicans | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
(1R,2S)-1-hydroxybutane-1,2,4-tricarboxylate | - |
Candida albicans | (Z)-but-1-ene-1,2,4-tricarboxylate + H2O | - |
? | |
(R)-homocitrate | - |
Candida albicans | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
Homoaconitase | - |
Candida albicans |
IC50 Value | IC50 Value Maximum | Comment | Organism | Inhibitor | Structure |
---|---|---|---|---|---|
1.58 | - |
in 50 mM Tris-HCl (pH 8.5), 50 mM KCl, 5 mM MgCl2, 20 mM dithiothreitol, at 20°C | Candida albicans | trans-homoaconitate | |
5.76 | - |
in 50 mM Tris-HCl (pH 8.5), 50 mM KCl, 5 mM MgCl2, 20 mM dithiothreitol, at 20°C | Candida albicans | tripotassium (1E)1,2-epoxy-butane-1,2,4-tricarboxylate |