Cloned (Comment) | Organism |
---|---|
- |
Mus musculus |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
ADP | significantly decreases activity with 5-oxo-D-proline and activity with D-glutamate | Mus musculus | |
ATP | significantly decreases activity with 5-oxo-D-proline and activity with D-glutamate | Mus musculus | |
EDTA | - |
Mus musculus | |
FAD | - |
Mus musculus | |
FMN | - |
Mus musculus | |
Mn2+ | completely abolishes activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
31.9 | - |
D-glutamate | pH 8.0, 37°C | Mus musculus |
Localization | Comment | Organism | GeneOntology No. | Textmining |
---|---|---|---|---|
mitochondrion | highly expressed in the mitochondrial matrix | Mus musculus | 5739 | - |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
CaCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
CuCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
MgCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
Mn2+ | completely abolishes activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus | |
ZnCl2 | no significant activity with 5-oxo-D-proline, stimulates activity with D-glutamate | Mus musculus |
Molecular Weight [Da] | Molecular Weight Maximum [Da] | Comment | Organism |
---|---|---|---|
146000 | - |
non-denaturing PAGE | Mus musculus |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
D-glutamate | Mus musculus | the metalloenzyme that degrades D-glutamate in the mitochondrial matrix in mammalian cells | 5-oxo-D-proline + H2O | - |
r |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Mus musculus | Q8BH86 | - |
- |
Purification (Comment) | Organism |
---|---|
- |
Mus musculus |
Source Tissue | Comment | Organism | Textmining |
---|---|---|---|
heart | highly expressed in the mitochondrial matrix in the heart | Mus musculus | - |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
5-oxo-D-proline + H2O | - |
Mus musculus | D-glutamate | - |
r | |
D-glutamate | - |
Mus musculus | 5-oxo-D-proline + H2O | - |
r | |
D-glutamate | the metalloenzyme that degrades D-glutamate in the mitochondrial matrix in mammalian cells | Mus musculus | 5-oxo-D-proline + H2O | - |
r |
Subunits | Comment | Organism |
---|---|---|
dimer | 2 * 65874, calculated from sequence | Mus musculus |
Synonyms | Comment | Organism |
---|---|---|
DGLUCY | - |
Mus musculus |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
7.67 | - |
5-oxo-D-proline | pH 8.0, 37°C | Mus musculus | |
35.6 | - |
D-glutamate | pH 8.0, 37°C | Mus musculus |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
8 | - |
- |
Mus musculus |
pH Minimum | pH Maximum | Comment | Organism |
---|---|---|---|
6 | 8 | small but significant increase in activity occurrs between pH 6.0 to 8.0 | Mus musculus |
General Information | Comment | Organism |
---|---|---|
metabolism | disrupts D-glutamate and/or 5-oxo-D-proline levels, contributing to the onset and/or exacerbation of heart failure | Mus musculus |
kcat/KM Value [1/mMs-1] | kcat/KM Value Maximum [1/mMs-1] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
1121 | - |
D-glutamate | pH 8.0, 37°C | Mus musculus |