Literature summary for 4.2.2.1 extracted from

de Assis, C.M.; Gandra, R.F.; Gambale, W.; Shimizu, M.T.; Paula, C.R.
Biosynthesis of chondroitinase and hyaluronidase by different strains of Paracoccidioides brasiliensis (2003), J. Med. Microbiol., 52, 479-481.

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Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
hyaluronan	Paracoccidioides brasiliensis	enzyme might be involved in the pathogenicity of the bacterium causing paracocidiodomycosis	3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine	-	?

Organism

Organism	UniProt	Comment	Textmining
Paracoccidioides brasiliensis	-	different strains isolated from different host organisms, e.g. human, penguin, armadillo, and from dog food	-

Reaction

Reaction	Comment	Organism	Reaction ID
[hyaluronate]n = (4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine-[hyaluronate]n-m-1 + 2 3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine + hyaluronate	also acts on chondroitin, the product is more systematically known as 3-(4-deoxy-alpha-L-threo-hex-4-enopyranosyluronic acid)-2-acetamido-2-deoxy-D-glucose	Paracoccidioides brasiliensis	a

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
hyaluronan	from umbilical cord	Paracoccidioides brasiliensis	3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine	-	?
hyaluronan	enzyme might be involved in the pathogenicity of the bacterium causing paracocidiodomycosis	Paracoccidioides brasiliensis	3-(4-deoxy-beta-D-gluc-4-enuronosyl)-N-acetyl-D-glucosamine	-	?

Synonyms

Synonyms	Comment	Organism
hyaluronidase	-	Paracoccidioides brasiliensis

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Release 2023.1 (January 2023)