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Literature summary for 4.2.2.1 extracted from
- CD44-dependent intracellular and extracellular catabolism of hyaluronic acid by hyaluronidase-1 and -2 (2007), J. Biol. Chem., 282, 5597-5607.
Activating Compound
| Activating Compound | Comment | Organism | Structure |
|---|---|---|---|
| CD44 | intracellular hyaluronic acid degradation is predominantly mediated by Hyal-1 after incorporation of hyaluronic acid by CD44 | Homo sapiens | |
| CD44 | without CD44 expression, Hyal-2 exists in a granular pattern, and does not show hyaluronidase activity | Homo sapiens |
Cloned(Commentary)
| Cloned (Comment) | Organism |
|---|---|
| 293 cells stably express Hyal-2 | Homo sapiens |
| Hyal-1/293 and Hyal-1/CD44/293 are stably overexpressing Hyal-1. The expressed Hyal-1 is not only accumulated intracellularly, but is also secreted to the outside of the cells | Homo sapiens |
Localization
| Localization | Comment | Organism | GeneOntology No. | Textmining |
|---|---|---|---|---|
| cell surface | - |
Homo sapiens | 9986 | - |
| membrane | Hyal-2 activityis detected in the membrane fraction of cells co-expressing Hyal-2 and CD44 | Homo sapiens | 16020 | - |
| additional information | although Hyal-1 is active only in intracellular space in vivo, a certain amount of the enzyme is secreted to extracellular space. This extracellular Hyal-1 is incorporated by cells and such uptake of Hyal-1 is, in part, involved in the intracellular degradation of hyaluronic acid | Homo sapiens | - |
- |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Homo sapiens | Q12794 | - |
- |
| Homo sapiens | Q12891 | - |
- |
Synonyms
| Synonyms | Comment | Organism |
|---|---|---|
| Hyal-1 | - |
Homo sapiens |
| Hyal-2 | - |
Homo sapiens |
| HYAL1 | - |
Homo sapiens |
| Hyal2 | - |
Homo sapiens |
| hyaluronidase-1 | - |
Homo sapiens |
| hyaluronidase-2 | - |
Homo sapiens |
| hyaluronoglucosaminidase-1 | - |
Homo sapiens |
| hyaluronoglucosaminidase-2 | - |
Homo sapiens |
| LUCA-1 | - |
Homo sapiens |
| LUCA-2 | - |
Homo sapiens |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 6 | 7 | Hyal-2 | Homo sapiens |
pH Range
| pH Minimum | pH Maximum | Comment | Organism |
|---|---|---|---|
| 5.5 | 7.5 | pH 5.5: about 55% of maximal activity, pH 7.5: about 40% of maximal activity | Homo sapiens |
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