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Literature summary for 4.2.2.19 extracted from
- Inhibition of hyaluronidases and chondroitinases by fatty acids (2002), J. Enzyme Inhib. Med. Chem., 17, 183-186.
Inhibitors
| Inhibitors | Comment | Organism | Structure |
|---|---|---|---|
| (13Z)-docos-13-enoic acid | strong inhibition | Pedobacter heparinus |  |
| arachidic acid | - |
Pedobacter heparinus | |
| behenic acid | - |
Pedobacter heparinus | |
| capric acid | - |
Pedobacter heparinus | |
| eicosadienoic acid | - |
Pedobacter heparinus | |
| eicosanoic acid | strong inhibition | Pedobacter heparinus | |
| eicosapentaenoic acid | - |
Pedobacter heparinus | |
| eicosatetraenoic acid | - |
Pedobacter heparinus | |
| eicosatrienoic acid | nonconmpetitive | Pedobacter heparinus | |
| elaidic acid | strong inhibition | Pedobacter heparinus | |
| lauric acid | - |
Pedobacter heparinus | |
| linoleic acid | strong inhibition | Pedobacter heparinus | |
| linolenic acid | strong inhibition | Pedobacter heparinus | |
| methyl (9Z)-octadecenoate | - |
Pedobacter heparinus | |
| additional information | degree of inhibition by fatty acids depends on the chain length and the number of unsaturated bonds as well as the stereochemistry, overview | Pedobacter heparinus | |
| myristic acid | - |
Pedobacter heparinus | |
| myristoleic acid | - |
Pedobacter heparinus | |
| nervonic acid | strong inhibition | Pedobacter heparinus | |
| oleic acid | strong inhibition | Pedobacter heparinus | |
| palmitic acid | - |
Pedobacter heparinus | |
| palmitoleic acid | - |
Pedobacter heparinus | |
| petroselinic acid | strong inhibition | Pedobacter heparinus | |
| ricinoleic acid | - |
Pedobacter heparinus | |
| stearic acid | - |
Pedobacter heparinus | |
| vaccenic acid | strong inhibition | Pedobacter heparinus | |
KM Value [mM]
| KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
|---|---|---|---|---|---|
| 0.0163 | - |
dermatan sulfate | pH 8.0, 37°C | Pedobacter heparinus | |
Organism
| Organism | UniProt | Comment | Textmining |
|---|---|---|---|
| Pedobacter heparinus | Q46079 | - |
- |
Substrates and Products (Substrate)
| Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
|---|---|---|---|---|---|---|
| dermatan sulfate | - |
Pedobacter heparinus | ? | - |
? | |
Temperature Optimum [°C]
| Temperature Optimum [°C] | Temperature Optimum Maximum [°C] | Comment | Organism |
|---|---|---|---|
| 30 | - |
assay at | Pedobacter heparinus |
pH Optimum
| pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
|---|---|---|---|
| 8 | - |
assay at, Tris-HCl | Pedobacter heparinus |
Ki Value [mM]
| Ki Value [mM] | Ki Value maximum [mM] | Inhibitor | Comment | Organism | Structure |
|---|---|---|---|---|---|
| additional information | - |
additional information | - |
Pedobacter heparinus | |
| 0.037 | - |
eicosatrienoic acid | pH 8.0, 37°C | Pedobacter heparinus | |
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Release 2023.1 (January 2023)
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