Literature summary for 4.2.3.17 extracted from

Williams, D.C.; Carroll, B.J.; Jin, Q.; Rithner, C.D.; Lenger, S.R.; Floss, H.G.; Coates, R.M.; Williams, R.M.; Croteau, R.
Intramolecular proton transfer in the cyclization of geranylgeranyl diphosphate to the taxadiene precursor of taxol catalyzed by recombinant taxadiene synthase (2000), Chem. Biol., 7, 969-977.

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Application

Application	Comment	Organism
medicine	chemotherapeutic agent against a range of cancers, including ovarian and breast cancer	Taxus brevifolia

Cloned(Commentary)

Cloned (Comment)	Organism
overexpression in Escherichia coli	Taxus brevifolia

Natural Substrates/ Products (Substrates)

Natural Substrates	Organism	Comment (Nat. Sub.)	Natural Products	Comment (Nat. Pro.)	Rev.	Reac.
geranylgeranyl diphosphate	Taxus brevifolia	catalyzes the first step in taxol biosynthesis	taxa-4,11-diene + diphosphate	-	?

Organism

Organism	UniProt	Comment	Textmining
Taxus brevifolia	-	-	-

Substrates and Products (Substrate)

Substrates	Comment Substrates	Organism	Products	Comment (Products)	Rev.	Reac.
geranylgeranyl diphosphate	-	Taxus brevifolia	taxa-4(5),11(12)-diene + diphosphate	-	?
geranylgeranyl diphosphate	catalyzes the first step in taxol biosynthesis	Taxus brevifolia	taxa-4,11-diene + diphosphate	-	?

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Release 2023.1 (January 2023)