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Literature summary for 4.2.3.18 extracted from

  • Criswell, J.; Potter, K.; Shephard, F.; Beale, M.H.; Peters, R.J.
    A single residue change leads to a hydroxylated product from the class II diterpene cyclization catalyzed by abietadiene synthase (2012), Org. Lett., 14, 5828-5831.
    View publication on PubMedView publication on EuropePMC

Protein Variants

Protein Variants Comment Organism
D621A this substitution eliminates the subsequently acting class I activity Abies grandis
H348A/D621A the mutant also produces 8alpha-hydroxy-copalyl diphosphate from geranylgeranyl diphosphate Abies grandis

Organism

Organism UniProt Comment Textmining
Abies grandis Q38710
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
geranylgeranyl diphosphate + diphosphate
-
Abies grandis (+)-copalyl diphosphate
-
?

Synonyms

Synonyms Comment Organism
abietadiene synthase
-
Abies grandis