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Literature summary for 4.2.99.18 extracted from

  • Warner, H.R.; Persson, M.L.; Bensen, R.J.; Mosbaugh, D.W.; Linn, S.
    Selective inhibition by harmane of apurinic/apyrimidinic endonuclease activity of phage T4-induced UV endonuclease (1981), Nucleic Acids Res., 9, 6083-6092.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
Harmane i.e. 1-methyl-9H-pyrido-[3,4-b]indole, inhibits Escherichia coli endonuclease III and its associated dihydroxythymidine-DNA glycosylase activity, 50% inhibition at 0.4 mM, 80% inhibition at 1 mM Escherichia coli
Harmane i.e. 1-methyl-9H-pyrido-[3,4-b]indole, only slight inhibition of AP endocunlease I and II Homo sapiens
Harmane i.e. 1-methyl-9H-pyrido-[3,4-b]indole, inhibits Escherichia coli endonuclease III and its associated dihydroxythymidine-DNA glycosylase activity, 50% inhibition at 0.4 mM, 80% inhibition at 1 mM Tequatrovirus T4

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA Escherichia coli
-
fragments of DNA
-
?
DNA Homo sapiens
-
fragments of DNA
-
?
DNA Tequatrovirus T4
-
fragments of DNA
-
?

Organism

Organism UniProt Comment Textmining
Escherichia coli
-
endonuclease III
-
Homo sapiens
-
-
-
Tequatrovirus T4
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
fibroblast
-
Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
Escherichia coli fragments of DNA
-
?
DNA
-
Homo sapiens fragments of DNA
-
?
DNA
-
Tequatrovirus T4 fragments of DNA
-
?
additional information
-
Homo sapiens ?
-
?
additional information
-
Tequatrovirus T4 ?
-
?
additional information enzyme also has DNA N-glycosylase activity Escherichia coli ?
-
?