Protein Variants | Comment | Organism |
---|---|---|
D210N | mutant enzyme is catalytically inactive against abasic sites in double-stranded DNA and single-stranded DNA | Homo sapiens |
DELTA1-29 | mutant enzyme retains activity against abasic sites in single-stranded DNA | Homo sapiens |
DELTA1-36 | mutant enzyme retains activity against abasic sites in single-stranded DNA | Homo sapiens |
Inhibitors | Comment | Organism | Structure |
---|---|---|---|
additional information | in contrast to activity against abasic sites in souble-stranded DNA the enzyme does not display product inhibition when acting on absic sites in single-stranded DNA | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.000024 | - |
double-stranded DNA with abasic sites | - |
Homo sapiens | |
0.000428 | - |
single-stranded DNA with abasic sites | - |
Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
Mg2+ | activity against abasic sites in single-stranded DNA | Homo sapiens |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
double-stranded DNA with abasic sites | - |
Homo sapiens | ? | - |
? | |
additional information | the enzyme remains bound to its incision product when the 5'-incision us in double-stranded DNA. The enzyme dissociates from its single-stranded 5'-incised product | Homo sapiens | ? | - |
? | |
single-stranded DNA with abasic sites | catalytic efficiency is 20fold less than the activity against double-stranded DNA with abasic sites | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AP endonuclease | - |
Homo sapiens |
APE1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
4.1 | - |
double-stranded DNA with abasic sites | - |
Homo sapiens | |
4.2 | - |
single-stranded DNA with abasic sites | - |
Homo sapiens |