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Literature summary for 4.2.99.18 extracted from

  • Faustoferri, R.C.; Hahn, K.; Weiss, K.; Quivey, R.G., Jr.
    Smx nuclease is the major, low-pH-inducible apurinic/apyrimidinic endonuclease in Streptococcus mutans (2005), J. Bacteriol., 187, 2705-2714.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.99.18

Cloned(Commentary)

Cloned (Comment) Organism
overexpression in Escherichia coli Streptococcus mutans

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
DNA containing apurinic/apyrimidinic sites Streptococcus mutans inducible enzyme, the enzyme exhibits endonucleolytic activity and is regulated as part of the acid-adaptive response of the organism. Smx is likely the primary, if not the sole, AP endonuclease induced during growth at low pH values, loss of Smx activity renders the mutant strain sensitive to hydrogen peroxide treatment but relatively unaffected by acid-mediated damage or near-UV irradiation fragments of DNA
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 ?
DNA containing apurinic/apyrimidinic sites Streptococcus mutans GS-5 inducible enzyme, the enzyme exhibits endonucleolytic activity and is regulated as part of the acid-adaptive response of the organism. Smx is likely the primary, if not the sole, AP endonuclease induced during growth at low pH values, loss of Smx activity renders the mutant strain sensitive to hydrogen peroxide treatment but relatively unaffected by acid-mediated damage or near-UV irradiation fragments of DNA
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 ?

Organism

Organism UniProt Comment Textmining
Streptococcus mutans Q9AIV4
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-
Streptococcus mutans GS-5 Q9AIV4
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-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA containing apurinic/apyrimidinic sites inducible enzyme, the enzyme exhibits endonucleolytic activity and is regulated as part of the acid-adaptive response of the organism. Smx is likely the primary, if not the sole, AP endonuclease induced during growth at low pH values, loss of Smx activity renders the mutant strain sensitive to hydrogen peroxide treatment but relatively unaffected by acid-mediated damage or near-UV irradiation Streptococcus mutans fragments of DNA
-
 ?
DNA containing apurinic/apyrimidinic sites inducible enzyme, the enzyme exhibits endonucleolytic activity and is regulated as part of the acid-adaptive response of the organism. Smx is likely the primary, if not the sole, AP endonuclease induced during growth at low pH values, loss of Smx activity renders the mutant strain sensitive to hydrogen peroxide treatment but relatively unaffected by acid-mediated damage or near-UV irradiation Streptococcus mutans GS-5 fragments of DNA
-
 ?

Synonyms

Synonyms Comment Organism
apurinic/apyrimidinic endonuclease
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 Streptococcus mutans
Smx nuclease
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 Streptococcus mutans