Inhibitors | Comment | Organism | Structure |
---|---|---|---|
KCl | maximal AP endonuclease activity at 25-200 mM, nucleotide incision repair activity decreases dramatically above 50 mM | Homo sapiens | |
MgCl2 | tetrahydrofuran*G incision activity is inhibited above 2 mM | Homo sapiens |
KM Value [mM] | KM Value Maximum [mM] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.0000027 | - |
duplex oligonucleotide containing a tetrahydrofuran*G pair | pH 6.8, 37°C, nucleotide incison repair activity | Homo sapiens | |
0.0000072 | - |
duplex oligonucleotide containing a alpha-2'-deoxyadenosine*T pair | pH 6.8, 37°C, nucleotide incison repair activity | Homo sapiens | |
0.0000084 | - |
duplex oligonucleotide containing a 5,6-dihydro-2'-deoxyuridine*G pair | pH 6.8, 37°C, nucleotide incison repair activity | Homo sapiens |
Metals/Ions | Comment | Organism | Structure |
---|---|---|---|
KCl | maximal AP endonuclease activity at 25-200 mM, nucleotide incision repair activity decreases dramatically above 50 mM | Homo sapiens | |
MgCl2 | tetrahydrofuran*G incision is efficiently catalyzed at 0.001 mM Mg2+, 5 mM MgCl2 are required for optimal AP endonuclease activity | Homo sapiens |
Natural Substrates | Organism | Comment (Nat. Sub.) | Natural Products | Comment (Nat. Pro.) | Rev. | Reac. |
---|---|---|---|---|---|---|
additional information | Homo sapiens | AP endonuclease Ape1 is involved in the nucleotide incision repair pathway | ? | - |
? |
Organism | UniProt | Comment | Textmining |
---|---|---|---|
Homo sapiens | - |
- |
- |
Substrates | Comment Substrates | Organism | Products | Comment (Products) | Rev. | Reac. |
---|---|---|---|---|---|---|
duplex oligonucleotide containing a 5,6-dihydro-2'-deoxyuridine*G pair | nucleotide incison repair activity | Homo sapiens | ? | - |
? | |
duplex oligonucleotide containing a alpha-2'-deoxyadenosine*T pair | nucleotide incison repair activity | Homo sapiens | ? | - |
? | |
duplex oligonucleotide containing a tetrahydrofuran*G pair | nucleotide incison repair activity | Homo sapiens | ? | - |
? | |
additional information | AP endonuclease Ape1 is involved in the nucleotide incision repair pathway | Homo sapiens | ? | - |
? |
Synonyms | Comment | Organism |
---|---|---|
AP endonuclease Ape1 | - |
Homo sapiens |
Turnover Number Minimum [1/s] | Turnover Number Maximum [1/s] | Substrate | Comment | Organism | Structure |
---|---|---|---|---|---|
0.002 | - |
duplex oligonucleotide containing a tetrahydrofuran*G pair | pH 6.8, 37°C, nucleotide incison repair activity | Homo sapiens | |
0.002 | - |
duplex oligonucleotide containing a alpha-2'-deoxyadenosine*T pair | pH 6.8, 37°C,nucleotide incison repair activity | Homo sapiens | |
0.0027 | - |
duplex oligonucleotide containing a 5,6-dihydro-2'-deoxyuridine*G pair | pH 6.8, 37°C, necleotide incison repair activity | Homo sapiens |
pH Optimum Minimum | pH Optimum Maximum | Comment | Organism |
---|---|---|---|
6.4 | 6.8 | nucleotide incision repair activity | Homo sapiens |
7.8 | 8.2 | AP endonuclease activity | Homo sapiens |