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Literature summary for 4.2.99.18 extracted from

  • Gros, L.; Ishchenko, A.A.; Ide, H.; Elder, R.H.; Saparbaev, M.K.
    The major human AP endonuclease (Ape1) is involved in the nucleotide incision repair pathway (2004), Nucleic Acids Res., 32, 73-81.
    View publication on PubMedView publication on EuropePMC

Inhibitors

Inhibitors Comment Organism Structure
KCl maximal AP endonuclease activity at 25-200 mM, nucleotide incision repair activity decreases dramatically above 50 mM Homo sapiens
MgCl2 tetrahydrofuran*G incision activity is inhibited above 2 mM Homo sapiens

KM Value [mM]

KM Value [mM] KM Value Maximum [mM] Substrate Comment Organism Structure
0.0000027
-
duplex oligonucleotide containing a tetrahydrofuran*G pair pH 6.8, 37°C, nucleotide incison repair activity Homo sapiens
0.0000072
-
duplex oligonucleotide containing a alpha-2'-deoxyadenosine*T pair pH 6.8, 37°C, nucleotide incison repair activity Homo sapiens
0.0000084
-
duplex oligonucleotide containing a 5,6-dihydro-2'-deoxyuridine*G pair pH 6.8, 37°C, nucleotide incison repair activity Homo sapiens

Metals/Ions

Metals/Ions Comment Organism Structure
KCl maximal AP endonuclease activity at 25-200 mM, nucleotide incision repair activity decreases dramatically above 50 mM Homo sapiens
MgCl2 tetrahydrofuran*G incision is efficiently catalyzed at 0.001 mM Mg2+, 5 mM MgCl2 are required for optimal AP endonuclease activity Homo sapiens

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
additional information Homo sapiens AP endonuclease Ape1 is involved in the nucleotide incision repair pathway ?
-
?

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
duplex oligonucleotide containing a 5,6-dihydro-2'-deoxyuridine*G pair nucleotide incison repair activity Homo sapiens ?
-
?
duplex oligonucleotide containing a alpha-2'-deoxyadenosine*T pair nucleotide incison repair activity Homo sapiens ?
-
?
duplex oligonucleotide containing a tetrahydrofuran*G pair nucleotide incison repair activity Homo sapiens ?
-
?
additional information AP endonuclease Ape1 is involved in the nucleotide incision repair pathway Homo sapiens ?
-
?

Synonyms

Synonyms Comment Organism
AP endonuclease Ape1
-
Homo sapiens

Turnover Number [1/s]

Turnover Number Minimum [1/s] Turnover Number Maximum [1/s] Substrate Comment Organism Structure
0.002
-
duplex oligonucleotide containing a tetrahydrofuran*G pair pH 6.8, 37°C, nucleotide incison repair activity Homo sapiens
0.002
-
duplex oligonucleotide containing a alpha-2'-deoxyadenosine*T pair pH 6.8, 37°C,nucleotide incison repair activity Homo sapiens
0.0027
-
duplex oligonucleotide containing a 5,6-dihydro-2'-deoxyuridine*G pair pH 6.8, 37°C, necleotide incison repair activity Homo sapiens

pH Optimum

pH Optimum Minimum pH Optimum Maximum Comment Organism
6.4 6.8 nucleotide incision repair activity Homo sapiens
7.8 8.2 AP endonuclease activity Homo sapiens