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Literature summary for 4.2.99.18 extracted from

  • Curtis, C.D.; Thorngren, D.L.; Ziegler, Y.S.; Sarkeshik, A.; Yates, J.R.; Nardulli, A.M.
    Apurinic/apyrimidinic endonuclease 1 alters estrogen receptor activity and estrogen-responsive gene expression (2009), Mol. Endocrinol., 23, 1346-1359.
    View publication on PubMedView publication on EuropePMC
Search for more literature for 4.2.99.18

Inhibitors

Inhibitors Comment Organism Structure
E3330 binds specifically to Ape1/Ref-1 and blocks its redox activity Homo sapiens
additional information methoxyamine binds to and occludes abasic sites in DNA and thereby inhibits Ape1/Ref-1-mediated DNA repair Homo sapiens

Organism

Organism UniProt Comment Textmining
Homo sapiens
-
-
-

Source Tissue

Source Tissue Comment Organism Textmining
MCF-7 cell
-
 Homo sapiens
-
U2-OS cell
-
 Homo sapiens
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
DNA
-
 Homo sapiens fragments of DNA
-
 ?

Synonyms

Synonyms Comment Organism
APE1
-
 Homo sapiens
apurinic/apyrimidinic endonuclease 1
-
 Homo sapiens
redox factor-1
-
 Homo sapiens
Ref-1
-
 Homo sapiens

General Information

General Information Comment Organism
malfunction knocking down Ape1/Ref-1 expression enhances estrogen responsiveness of the progesterone receptor and pS2 genes but does not alter the expression of the constitutively active 36B4 gene Homo sapiens
physiological function Ape1/Ref-1 enhances the interaction of estrogen receptor alpha with estrogen-response elements in DNA, Ape1/Ref-1 alters expression of the endogenous, estrogen-responsive progesterone receptor and pS2 genes in MCF-7 cells and associates with estrogen-response elements-containing regions of these genes in native chromatin Homo sapiens