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Literature summary for 4.3.1.2 extracted from

  • Gani, D.; Archer, C.H.; Botting, N.P.; Pollard, J.R.
    The methylaspartase reaction probed using 2H- and 15N-isotope E ects for three substrates: A flip from a concerted to a carbocationic amino-enzyme elimination mechanism upon changing the C-3 stereochemistry in the substrate from R to S (1999), Bioorg. Med. Chem., 7, 977-990.
    View publication on PubMed
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Inhibitors

Inhibitors Comment Organism Structure
N-ethylmaleimide irreversible Clostridium tetanomorphum

Metals/Ions

Metals/Ions Comment Organism Structure
K+
-
 Clostridium tetanomorphum
Mg2+
-
 Clostridium tetanomorphum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-threo-3-methylaspartate Clostridium tetanomorphum
-
 mesaconate + NH3
-
 r
L-threo-3-methylaspartate Clostridium tetanomorphum
-
 ?
-
 ?
L-threo-3-methylaspartate Clostridium tetanomorphum H1 / ATCC 15920
-
 mesaconate + NH3
-
 r

Organism

Organism UniProt Comment Textmining
Clostridium tetanomorphum
-
-
-
Clostridium tetanomorphum
-
 ATCC 15920
-
Clostridium tetanomorphum H1 / ATCC 15920
-
-
-

Purification (Commentary)

Purification (Comment) Organism
-
 Clostridium tetanomorphum

Reaction

Reaction Comment Organism Reaction ID
L-threo-3-methylaspartate = mesaconate + NH3 mechanism Clostridium tetanomorphum
a
L-threo-3-methylaspartate = mesaconate + NH3 carbon mechanism Clostridium tetanomorphum
a

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
(2S)-aspartate
-
 Clostridium tetanomorphum fumarate + NH3
-
 ?
erythro-3-methylaspartate (2S,3R)-3-methylaspartic acid Clostridium tetanomorphum ?
-
 ?
L-aspartate (2S)-aspartate Clostridium tetanomorphum fumarate + NH3
-
 ?
L-aspartate (2S)-aspartate Clostridium tetanomorphum H1 / ATCC 15920 fumarate + NH3
-
 ?
L-erythro-3-methylaspartate i.e. (2S,3R)-3-methylaspartate, slow syn elimination Clostridium tetanomorphum mesaconate + NH3
-
 ?
L-threo-3-methylaspartate
-
 Clostridium tetanomorphum mesaconate + NH3
-
 r
L-threo-3-methylaspartate r Clostridium tetanomorphum mesaconate + NH3
-
 ?
L-threo-3-methylaspartate (2S,3S)-3-methylaspartic acid Clostridium tetanomorphum mesaconate + NH3
-
 ?
L-threo-3-methylaspartate i.e. (2S,3S)-3-methylaspartate Clostridium tetanomorphum mesaconate + NH3
-
 r
L-threo-3-methylaspartate
-
 Clostridium tetanomorphum H1 / ATCC 15920 mesaconate + NH3
-
 r
L-threo-3-methylaspartate r Clostridium tetanomorphum H1 / ATCC 15920 mesaconate + NH3
-
 ?
L-threo-3-methylaspartate (2S,3S)-3-methylaspartic acid Clostridium tetanomorphum H1 / ATCC 15920 mesaconate + NH3
-
 ?
L-threo-3-methylaspartate i.e. (2S,3S)-3-methylaspartate Clostridium tetanomorphum H1 / ATCC 15920 mesaconate + NH3
-
 r
L-threo-3-methylaspartate
-
 Clostridium tetanomorphum ?
-
 ?