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Literature summary for 4.3.1.24 extracted from

  • Zon, J.; Miziak, P.
    1-Aminobenzocyclobutene-1-phosphonic acid and related compounds as inhibitors of phenylalanine ammonia-lyase (2017), Chem. Biodivers., 14, e1600488 .
    View publication on PubMed
Search for more literature for 4.3.1.24

Inhibitors

Inhibitors Comment Organism Structure
(2-amino-2,3-dihydro-1H-inden-2-yl)phosphonic acid powerful inhibitor Fagopyrum esculentum
(R)-1-amino-2-phenylethylphosphonic acid
-
 Fagopyrum esculentum
(S)-2-aminooxy-3-phenylpropionic acid
-
 Fagopyrum esculentum
1-aminobenzocyclobutene-1-phosphonic acid six times weaker than the inhibitor 1-aminobenzocyclobutene-1-phosphonic acid Fagopyrum esculentum

Natural Substrates/ Products (Substrates)

Natural Substrates Organism Comment (Nat. Sub.) Natural Products Comment (Nat. Pro.) Rev. Reac.
L-phenylalanine Fagopyrum esculentum enzyme of the plant phenylpropanoid pathway trans-cinnamate + NH3
-
 ?

Organism

Organism UniProt Comment Textmining
Fagopyrum esculentum
-
-
-

Substrates and Products (Substrate)

Substrates Comment Substrates Organism Products Comment (Products) Rev. Reac.
L-phenylalanine
-
 Fagopyrum esculentum trans-cinnamate + NH3
-
 ?
L-phenylalanine enzyme of the plant phenylpropanoid pathway Fagopyrum esculentum trans-cinnamate + NH3
-
 ?

Ki Value [mM]

Ki Value [mM] Ki Value maximum [mM] Inhibitor Comment Organism Structure
0.000047
-
 (2-amino-2,3-dihydro-1H-inden-2-yl)phosphonic acid pH and temperature not specified in the publication Fagopyrum esculentum
0.00032
-
 1-aminobenzocyclobutene-1-phosphonic acid pH and temperature not specified in the publication Fagopyrum esculentum

General Information

General Information Comment Organism
metabolism enzyme of the plant phenylpropanoid pathway Fagopyrum esculentum